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Anti-LPAR1 Antibody (3T102)

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Anti-LPAR1 Antibody (3T102)
产品编号 TMAH-00702
别名 Lysophosphatidic acid receptor Edg-2, Lysophosphatidic acid receptor 1, LPAR 1, LPA-1, LPA1, LPA receptor 1, EDG2

Anti-LPAR1 Antibody (3T102) 是一种抗体,靶向 LPAR1。Anti-LPAR1 Antibody (3T102) 可用于 ELISA, WB。

Anti-LPAR1 Antibody (3T102)

Anti-LPAR1 Antibody (3T102)

Rating icon 还可以
Anti-LPAR1 Antibody (3T102)
产品编号 TMAH-00702 别名 Lysophosphatidic acid receptor Edg-2, Lysophosphatidic acid receptor 1, LPAR 1, LPA-1, LPA1, LPA receptor 1, EDG2

Anti-LPAR1 Antibody (3T102) 是一种抗体,靶向 LPAR1。Anti-LPAR1 Antibody (3T102) 可用于 ELISA, WB。

规格价格库存数量
50 μL
¥ 1,305
5日内发货
100 μL
¥ 2,190
5日内发货
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产品介绍

生物活性
产品描述
Anti-LPAR1 Antibody (3T102) is an antibody targeting LPAR1. Anti-LPAR1 Antibody (3T102) can be used in ELISA, WB.
别名Lysophosphatidic acid receptor Edg-2, Lysophosphatidic acid receptor 1, LPAR 1, LPA-1, LPA1, LPA receptor 1, EDG2
Ig Type
Rabbit IgG
克隆号
3T102
交叉反应
Human
验证活性
Western Blot
-Positive WB detected in: Hela whole cell lysate, A375 whole cell lysate
-All lanes: EDG2 antibody at 1:1000
-Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution
-Predicted band size: 42, 42 kDa
-Observed band size: 42 kDa
应用
推荐剂量
WB:1:500-1:5000.
抗体种类
Monoclonal
亚细胞定位Cell surface. Cell membrane; Multi-pass membrane protein. Endosome.
构建方式Recombinant Antibody
纯化方式Affinity-chromatography
性状Liquid
缓冲液Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
研究背景Receptor for lysophosphatidic acid (LPA). Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels. Signaling triggers an increase of cytoplasmic Ca(2+) levels. Activates RALA; this leads to the activation of phospholipase C (PLC) and the formation of inositol 1,4,5-trisphosphate. Signaling mediates activation of down-stream MAP kinases. Contributes to the regulation of cell shape. Promotes Rho-dependent reorganization of the actin cytoskeleton in neuronal cells and neurite retraction. Promotes the activation of Rho and the formation of actin stress fibers. Promotes formation of lamellipodia at the leading edge of migrating cells via activation of RAC1. Through its function as lysophosphatidic acid receptor, plays a role in chemotaxis and cell migration, including responses to injury and wounding. Plays a role in triggering inflammation in response to bacterial lipopolysaccharide (LPS) via its interaction with CD14. Promotes cell proliferation in response to lysophosphatidic acid. Required for normal skeleton development. May play a role in osteoblast differentiation. Required for normal brain development. Required for normal proliferation, survival and maturation of newly formed neurons in the adult dentate gyrus. Plays a role in pain perception and in the initiation of neuropathic pain.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
A synthetic peptide: Human EDG2
抗原种属
Human
基因ID
Uniprot ID
研究领域
Cancer, Cardiovascular, Metabolism, Signal transduction
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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