还可以
Anti-LPAR1 Antibody (3T102) 是一种抗体，靶向 LPAR1。Anti-LPAR1 Antibody (3T102) 可用于 ELISA, WB。
还可以Anti-LPAR1 Antibody (3T102) 是一种抗体，靶向 LPAR1。Anti-LPAR1 Antibody (3T102) 可用于 ELISA, WB。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,305 | 5日内发货 | |
| 100 μL | ¥ 2,190 | 5日内发货 |
| 产品描述 | Anti-LPAR1 Antibody (3T102) is an antibody targeting LPAR1. Anti-LPAR1 Antibody (3T102) can be used in ELISA, WB. |
| 别名 | Lysophosphatidic acid receptor Edg-2, Lysophosphatidic acid receptor 1, LPAR 1, LPA-1, LPA1, LPA receptor 1, EDG2 |
| Ig Type | Rabbit IgG |
| 克隆号 | 3T102 |
| 交叉反应 | Human |
| 验证活性 | Western Blot -Positive WB detected in: Hela whole cell lysate, A375 whole cell lysate -All lanes: EDG2 antibody at 1:1000 -Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution -Predicted band size: 42, 42 kDa -Observed band size: 42 kDa |
| 应用 | ELISA, WB |
| 推荐剂量 | WB:1:500-1:5000. |
| 抗体种类 | Monoclonal |
| 亚细胞定位 | Cell surface. Cell membrane; Multi-pass membrane protein. Endosome. |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | Affinity-chromatography |
| 性状 | Liquid |
| 缓冲液 | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 研究背景 | Receptor for lysophosphatidic acid (LPA). Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels. Signaling triggers an increase of cytoplasmic Ca(2+) levels. Activates RALA; this leads to the activation of phospholipase C (PLC) and the formation of inositol 1,4,5-trisphosphate. Signaling mediates activation of down-stream MAP kinases. Contributes to the regulation of cell shape. Promotes Rho-dependent reorganization of the actin cytoskeleton in neuronal cells and neurite retraction. Promotes the activation of Rho and the formation of actin stress fibers. Promotes formation of lamellipodia at the leading edge of migrating cells via activation of RAC1. Through its function as lysophosphatidic acid receptor, plays a role in chemotaxis and cell migration, including responses to injury and wounding. Plays a role in triggering inflammation in response to bacterial lipopolysaccharide (LPS) via its interaction with CD14. Promotes cell proliferation in response to lysophosphatidic acid. Required for normal skeleton development. May play a role in osteoblast differentiation. Required for normal brain development. Required for normal proliferation, survival and maturation of newly formed neurons in the adult dentate gyrus. Plays a role in pain perception and in the initiation of neuropathic pain. |
| 偶联 | Unconjugated |
| 免疫原 | A synthetic peptide: Human EDG2 |
| 抗原种属 | Human |
| 基因ID | 1902 |
| Uniprot ID | |
| 研究领域 | Cancer, Cardiovascular, Metabolism, Signal transduction |
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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