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Anti-Phospho-AKT1/2/3 (Tyr315/316/312) Polyclonal Antibody

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Anti-Phospho-AKT1/2/3 (Tyr315/316/312) Polyclonal Antibody
产品编号 TMAC-00128
别名 p-AKT1/2/3 (Y315/316/312), p-AKT1/2/3 (Tyr315/316/312), AKT1/2/3 (p-Y315/316/312), AKT1/2/3 (p-Tyr315/316/312)

Anti-Phospho-AKT1/2/3 (Tyr315/316/312) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-AKT1/2/3 (Tyr315/316/312)。Anti-Phospho-AKT1/2/3 (Tyr315/316/312) Polyclonal Antibody 可用于 WB,IHC,IF。

Anti-Phospho-AKT1/2/3 (Tyr315/316/312) Polyclonal Antibody

Anti-Phospho-AKT1/2/3 (Tyr315/316/312) Polyclonal Antibody

Rating icon 还可以
Anti-Phospho-AKT1/2/3 (Tyr315/316/312) Polyclonal Antibody
产品编号 TMAC-00128 别名 p-AKT1/2/3 (Y315/316/312), p-AKT1/2/3 (Tyr315/316/312), AKT1/2/3 (p-Y315/316/312), AKT1/2/3 (p-Tyr315/316/312)

Anti-Phospho-AKT1/2/3 (Tyr315/316/312) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-AKT1/2/3 (Tyr315/316/312)。Anti-Phospho-AKT1/2/3 (Tyr315/316/312) Polyclonal Antibody 可用于 WB,IHC,IF。

规格价格库存数量
50 μL
¥ 1,490
5日内发货
100 μL
¥ 2,245
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-AKT1/2/3 (Tyr315/316/312) Polyclonal Antibody is a Rabbit antibody targeting Phospho-AKT1/2/3 (Tyr315/316/312). Anti-Phospho-AKT1/2/3 (Tyr315/316/312) Polyclonal Antibody can be used in WB,IHC,IF.
别名p-AKT1/2/3 (Y315/316/312), p-AKT1/2/3 (Tyr315/316/312), AKT1/2/3 (p-Y315/316/312), AKT1/2/3 (p-Tyr315/316/312)
Ig Type
IgG
交叉反应
Human,Mouse,Rat
验证活性
1. Western blot analysis of extracts from HepG2 cells untreated or treated with EGF using AKT1/AKT2/AKT3(phospho-Tyr315/316/312) Antibody TMAC-00128.
2. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using AKT1/AKT2/AKT3(Phospho-Tyr315/316/312) Antibody TMAC-00128(left) or the same antibody preincubated with blocking peptide(right).
3. Immunofluorescence staining of methanol-fixed Hela cells using AKT1/AKT2/AKT3(phospho-Tyr315/316/312) Antibody TMAC-00128.
4. Western blot analysis of extracts from 3T3 cells, treated with EGF or calf intestinal phosphatase (CIP), using AKT1/AKT2/AKT3 (phospho-Tyr315/316/312) Antibody TMAC-00128.
5. Western blot analysis of extracts of various cell lines, using AKT1/AKT2/AKT3(phospho-Tyr315/316/312) Antibody.
应用
WB
IHC
IF
抗体种类
Polyclonal
宿主来源Rabbit
构建方式Polyclonal Antibody
纯化方式Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
性状Liquid
缓冲液Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
研究背景General protein kinase capable of phosphorylating several known proteins. Phosphorylates TBC1D4. Signals downstream of phosphatidylinositol 3-kinase (PI3K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). Plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. Mediates the antiapoptotic effects of IGF-I. Mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. Promotes glycogen synthesis by mediating the insulin-induced activation of glycogen synthase. /General protein kinase capable of phosphorylating several known proteins. IGF-1 leads to the activation of AKT3, which may play a role in regulating cell survival. Capable of phosphorylating several known proteins. Truncated isoform 2/PKB gamma 1 without the second serine phosphorylation site could still be stimulated but to a lesser extent.
偶联与修饰
偶联
Unconjugated
其他可选修饰符
Phospho
抗原信息
免疫原
Peptide sequence around phosphorylation site of tyrosine 315/316/312 (P-E-Y(p)-L-A) derived from Human AKT1/AKT2/AKT3
抗原种属
human
Uniprot ID
P31749 & P31751 & Q9WUA6-1
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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关键词

pAKT1/2/3 (Y315/316/312)pAKT1/2/3 (Tyr315/316/312)AKT1/2/3 (pY315/316/312)AKT1/2/3 (pTyr315/316/312)AKT1/2/3 (phospho-Y315/316/312)AKT1/2/3 (phospho-Tyr315/316/312)

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