购物车

您的购物车当前为空

ABT 102

Name: ABT 102
Brand: TargetMol
SKU: T29522
Price: 780 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 99.86%

货号 T29522Cas号 808756-71-0

别名 CHEMBL398338, ABT-102, ABT102

ABT 102 (CHEMBL398338) 是瞬时受体电位香草素 1 (TRPV1) 受体的选择性拮抗剂。

为众多的药物研发团队赋能，

让新药发现更简单！

ABT 102

一键复制产品信息

很棒

纯度: 99.86%

货号 T29522 别名 CHEMBL398338, ABT-102, ABT102Cas号 808756-71-0

ABT 102 (CHEMBL398338) 是瞬时受体电位香草素 1 (TRPV1) 受体的选择性拮抗剂。

规格	价格	库存
1 mg	¥ 780	现货
5 mg	¥ 1,750	现货
10 mg	¥ 2,590	现货
25 mg	¥ 4,120	现货
50 mg	¥ 5,590	现货
100 mg	¥ 7,500	现货
200 mg	¥ 9,870	现货
1 mL x 10 mM (in DMSO)	¥ 1,730	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

加入购物车

该分子属于定制产品。TargetMol拥有优秀的合成团队，经验和能力，可以为您提供高性价比的产品。如您有任何问题，欢迎咨询，我们将竭诚为您服务。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.86%

ee: 99.58%

联系我们获取更多批次信息

资源下载:

COA CSFC LCMS HNMR 产品操作手册

产品介绍

ABT 102 AI Summary

ABT 102 is a potent antagonist of the human TRPV1 receptor, exhibiting an IC50 of 4.0 nM for capsaicin-induced calcium flux and 0.7 nM for pH 5.5-induced activation. It also shows inhibitory activity against N-arachidonoyl-dopamine with an IC50 of 3.0 nM. The compound displays high permeability across human Caco-2 cells (Papp > 18.0 x 10^-6 cm/s) and demonstrates strong plasma protein binding (PPB 99.78%). In rats, ABT 102 has a half-life of 1.7 hours, a volume of distribution beta of 2.8 L/kg, and plasma clearance of 18.33 mL/min/kg when administered intravenously at 10 μmol/kg in PEG400. It exhibits a Cmax of 717.46 nM and an oral bioavailability of 70.0% under similar dosing conditions. Additionally, the compound decreases carrageenan-induced thermal hyperalgesia in Sprague-Dawley rats with an ED50 of 20.0 μmol/kg and shows a brain-to-plasma ratio of 0.32. The variable intrinsic clearance rates in human liver microsomes (8.32 mL/min/g) compared to rat (20.42 μL/min/(10^6 cells)) and its low intrinsic clearance in human assays suggest metabolic differences. ABT 102 demonstrates mixed effects on cell viability across different cell lines and induces hyperthermia in rats, increasing body temperature by 0.8°C. It also has varying oral bioavailability in dogs and monkeys depending on the administered dose and vehicle..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	ABT 102 (CHEMBL398338) is a selective antagonist of transient receptor potential vanilloid 1 (TRPV1) receptor.
别名	CHEMBL398338, ABT-102, ABT102

化学信息

分子量	348.44
分子式	C₂₁H₂₄N₄O
CAS No.	808756-71-0
Smiles	N(C(NC1=C2C(NN=C2)=CC=C1)=O)[C@H]3C=4C(=CC(C(C)(C)C)=CC4)CC3
密度	1.31g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 45 mg/mL (129.15 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2 mg/mL (5.74 mM), Sonication is recommeded.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8699 mL	14.3497 mL	28.6993 mL	143.4967 mL
5 mM	0.5740 mL	2.8699 mL	5.7399 mL	28.6993 mL
10 mM	0.2870 mL	1.4350 mL	2.8699 mL	14.3497 mL
20 mM	0.1435 mL	0.7175 mL	1.4350 mL	7.1748 mL
50 mM	0.0574 mL	0.2870 mL	0.5740 mL	2.8699 mL
100 mM	0.0287 mL	0.1435 mL	0.2870 mL	1.4350 mL