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Fas/CD95 Protein, Mouse, Recombinant (hFc)

Fas/CD95 Protein, Mouse, Recombinant (hFc)

产品编号 TMPJ-00215
别名: CD95, Apoptosis-mediating surface antigen FAS, TNFRSF6, Fas, Tumor necrosis factor receptor superfamily member 6, FASLG receptor, Apo-1 antigen

Mouse Apoptosis-mediating surface antigen FAS (Fas) belongs to the death receptor subfamily of the TNF receptor superfamily and is designated TNFRSF6. Mouse Fas contains 1 death domain and 3 TNFR-Cys repeats. It detected in various tissues including thymus, liver, lung, heart, and adult ovary. As a receptor for TNFSF6/FASLG, The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both.

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Fas/CD95 Protein, Mouse, Recombinant (hFc)
规格 价格/CNY 货期 数量
10 μg ¥ 740 5日内发货
50 μg ¥ 1,970 5日内发货
500 μg ¥ 12,100 5日内发货
1 mg ¥ 17,400 5日内发货
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产品目录号及名称: Fas/CD95 Protein, Mouse, Recombinant (hFc) (TMPJ-00215)
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产品描述 Mouse Apoptosis-mediating surface antigen FAS (Fas) belongs to the death receptor subfamily of the TNF receptor superfamily and is designated TNFRSF6. Mouse Fas contains 1 death domain and 3 TNFR-Cys repeats. It detected in various tissues including thymus, liver, lung, heart, and adult ovary. As a receptor for TNFSF6/FASLG, The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both.
种属 Mouse
表达系统 Human Cells
标签 C-Fc
蛋白编号 P25446
别名 CD95, Apoptosis-mediating surface antigen FAS, TNFRSF6, Fas, Tumor necrosis factor receptor superfamily member 6, FASLG receptor, Apo-1 antigen
氨基酸序列 Gln22-Arg169
蛋白构建 Recombinant Mouse Apoptosis-mediating Surface Antigen FAS is produced by our Mammalian expression system and the target gene encoding Gln22-Arg169 is expressed with a human IgG1 Fc tag at the C-terminus.
蛋白纯度 Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
分子量 55 KDa, reducing conditions
内毒素 Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
缓冲液 Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
复溶方法 Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. 
存储

Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

运输方式

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.

研究背景 Mouse Apoptosis-mediating surface antigen FAS (Fas) belongs to the death receptor subfamily of the TNF receptor superfamily and is designated TNFRSF6. Mouse Fas contains 1 death domain and 3 TNFR-Cys repeats. It detected in various tissues including thymus, liver, lung, heart, and adult ovary. As a receptor for TNFSF6/FASLG, The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both.

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Keywords

Fas/CD95 Protein, Mouse, Recombinant (hFc) CD95 Apoptosis-mediating surface antigen FAS TNFRSF 6 TNFRSF6 Fas Tumor necrosis factor receptor superfamily member 6 FASLG receptor CD 95 CD-95 TNFRSF-6 Apo-1 antigen recombinant recombinant-proteins proteins protein

 

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