ICOS ligand Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 26.69 kDa and the accession number is NP_056074.1.
生物活性 | Immobilized Recombinant Human ICOS ligand Protein (ECD) at 2 μg/ml (100 μl/well) can bind Recombinant Human ICOS / AILIM / CD278 Protein (His & Fc Tag) , the EC50 is 8-25 ng/mL. |
产品描述 | ICOS ligand Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 26.69 kDa and the accession number is NP_056074.1. |
种属 | Human |
表达系统 | HEK293 Cells |
标签 | Tag Free |
蛋白编号 | NP_056074.1 |
别名 | ICOS ligand, LICOS, ICOSLG, B7-h2, B7RP1, CD275, B7H2, GL50, B7RP-1, inducible T-cell co-stimulator ligand, ICOSL, ICOS-L |
蛋白构建 | Human ICOS ligand (NP_056074.1) (Met1-Ser258) |
蛋白纯度 | ≥ 95 % as determined by SDS-PAGE. ≥ 95 % as determined by SEC-HPLC. |
分子量 | 26.69 kDa (predicted) |
内毒素 | < 1.0 EU/μg of the protein as determined by the LAL method. |
缓冲液 | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
复溶方法 | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
存储 |
It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
运输方式 |
In general, Lyophilized powders are shipping with blue ice. |
研究背景 | Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmembrane glycoprotein with extracellular IgV and IgC domains and binds to ICOS on activated T cells, thus delivers a positive costimulatory signal for optimal T cell function. The structural features of ICOSL are crucial for its costimulatory function. The present study shows that ICOSL displays a marked oligomerization potential, resembling more like B7-1 than B7-2. B7-H2-dependent signaling may play an active role in a proliferative response rather than in cytokine and chemokine production. The CD28/B7 and ICOS/B7-H2 pathways are both critical for costimulating T cell immune responses. Deficiency in either pathway results in defective T cell activation, cytokine production, and germinal center formation.Cancer ImmunotherapyCo-stimulatory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint Detection: AntibodiesImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint Detection: FCM AntibodiesImmune Checkpoint Detection: WB AntibodiesImmune Checkpoint TargetsImmunotherapyTargeted Therapy |
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ICOS ligand Protein, Human, Recombinant ICOS ligand LICOS ICOSLG B7-h2 B7RP1 CD275 GL 50 B7H2 CD-275 GL50 B7RP-1 CD 275 inducible T-cell co-stimulator ligand GL-50 ICOSL ICOS-L recombinant recombinant-proteins proteins protein