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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-MAEL/CT128 Polyclonal Antibody

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货号 TMAB-08505

Anti-MAEL/CT128 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 MAEL/CT128。Anti-MAEL/CT128 Polyclonal Antibody 可用于 ICC/IF。

Anti-MAEL/CT128 Polyclonal Antibody

Anti-MAEL/CT128 Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-08505

Anti-MAEL/CT128 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 MAEL/CT128。Anti-MAEL/CT128 Polyclonal Antibody 可用于 ICC/IF。

规格价格库存数量
50 μL
¥ 1,160
5日内发货
100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,785
5日内发货
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产品介绍

生物活性
产品描述
Anti-MAEL/CT128 Polyclonal Antibody is a Rabbit antibody targeting MAEL/CT128. Anti-MAEL/CT128 Polyclonal Antibody can be used in ICC/IF.
Ig Type
IgG
反应种属
Human (predicted:Mouse,Rat,Dog,Pig,Cow,Horse,Sheep)
应用ICC/IF
推荐剂量
ICC/IF: 1:50-200
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasm. Nucleus. Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon during meiosis. Specifically localizes to piP-bodies, a subset of the nuage which contains secondary piRNAs.
组织特异性Testis-specific. Expressed in various cancer cell lines, probably due to demethylation of its promoter.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Mael is a 434 amino acid protein that localizes to both the nucleus and the cytoplasm and contains one HMG box DNA-binding domain. Expressed specifically in testicular tissue, Mael interacts with Ini1, mSin3B and VASA and plays an essential role in spermatogenesis, specifically by repressing and, ultimately, preventing the mobilization of transposable elements (a process that is crucial for germline integrity). Multiple isoforms of Mael exist due to alternative splicing events. The gene encoding Mael maps to human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson’s disease, Gaucher disease, schizophrenia and Usher syndrome. Aberrations in chromosome 1 are found in a variety of cancers, including head and neck cancer, malignant melanoma and multiple myeloma.
抗原信息
免疫原
KLH conjugated synthetic peptide: human MAEL/CT128
抗原种属
Human
基因名称
MAEL
基因ID
84944
蛋白名称
Protein maelstrom homolog
Uniprot ID
Q96JY0
功能
Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for localization of germ-cell factors to the meiotic nuage.
化学信息
分子量Theoretical: 49 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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