CD3 epsilon/CD3e Protein, Cynomolgus, Recombinant (aa 22-117, hFc)

产品编号 TMPJ-01259

别名: CD3 epsilon, T-cell antigen receptor complex, epsilon subunit of T3, CD3e antigen, ε polypeptide (TiT3 complex), T-cell surface antigen T3/Leu-4 epsilon chain, CD3e antigen, epsilon polypeptide (TiT3 complex), T-cell antigen receptor complex, ε subunit of T3, CD3e antigen, FLJ18683, CD3e, CD3e molecule, epsilon (CD3-TCR complex), CD3 ε, CD3e molecule, ε (CD3-TCR complex), T3E, CD3-epsilon, T-cell surface antigen T3/Leu-4 ε chain, CD3-ε

T-cell surface glycoprotein CD3 epsilon chain, also known as CD3E, is a single-pass type I membrane protein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. The CD3 epsilon subunit of the T cell receptor (TCR) complex contains two defined signaling domains, a proline-rich sequence and an immune tyrosine activation motifs (ITAMs), and this complex undergoes a conformational change upon ligand binding that is thought to be important for the activation of T cells. T cell receptor-CD3 complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. This complex is critical for T-cell development and function, and represents one of the most complex transmembrane receptors. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. Homozygous mutations in CD3D and CD3E genes lead to a complete block in T-cell development and thus to an early-onset severe combined immunodeficiency phenotype.

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CD3 epsilon/CD3e Protein, Cynomolgus, Recombinant (aa 22-117, hFc)

规格	价格/CNY	货期
10 μg	￥ 820	5日内发货
50 μg	￥ 2,480	5日内发货
500 μg	￥ 12,100	5日内发货
1 mg	￥ 17,400	5日内发货

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产品描述

种属	Cynomolgus
表达系统	HEK293 Cells
标签	C-hFc
蛋白编号	Q95LI5
别名	CD3 epsilon, T-cell antigen receptor complex, epsilon subunit of T3, CD3e antigen, ε polypeptide (TiT3 complex), T-cell surface antigen T3/Leu-4 epsilon chain, CD3e antigen, epsilon polypeptide (TiT3 complex), T-cell antigen receptor complex, ε subunit of T3, CD3e antigen, FLJ18683, CD3e, CD3e molecule, epsilon (CD3-TCR complex), CD3 ε, CD3e molecule, ε (CD3-TCR complex), T3E, CD3-epsilon, T-cell surface antigen T3/Leu-4 ε chain, CD3-ε
氨基酸序列	Gln22-Asp117
蛋白构建	Gln22-Asp117
蛋白纯度	Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
分子量	38-55 KDa (reducing condition)

内毒素	< 0.1 ng/µg (1 EU/µg) as determined by LAL test.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing 50 mM Tris-HCl, 100 mM Glycine, pH 7.5.
复溶方法	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
存储	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
研究背景	T-cell surface glycoprotein CD3 epsilon chain, also known as CD3E, is a single-pass type I membrane protein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. The CD3 epsilon subunit of the T cell receptor (TCR) complex contains two defined signaling domains, a proline-rich sequence and an immune tyrosine activation motifs (ITAMs), and this complex undergoes a conformational change upon ligand binding that is thought to be important for the activation of T cells. T cell receptor-CD3 complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. This complex is critical for T-cell development and function, and represents one of the most complex transmembrane receptors. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. Homozygous mutations in CD3D and CD3E genes lead to a complete block in T-cell development and thus to an early-onset severe combined immunodeficiency phenotype.

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Keywords

CD3 epsilon/CD3e Protein, Cynomolgus, Recombinant (aa 22-117, hFc) CD3 epsilon CD3e molecule, epsilon T-cell antigen receptor complex, epsilon subunit of T3 CD3e antigen, ε polypeptide (TiT3 complex) T-cell surface antigen T3/Leu-4 epsilon chain CD3e antigen, epsilon polypeptide CD3-TCR complex CD3e antigen, epsilon polypeptide (TiT3 complex) T-cell antigen receptor complex, ε subunit of T3 CD3e antigen FLJ18683 TiT3 complex CD3e CD3e molecule, epsilon (CD3-TCR complex) CD3 ε CD3e molecule, ε (CD3-TCR complex) T3E FLJ 18683 FLJ-18683 CD3-epsilon T-cell surface antigen T3/Leu-4 ε chain CD3-ε recombinant recombinant-proteins proteins protein