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Anti-ICOS ligand Antibody-APC (1W488)
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产品编号 TMAY-01901A
别名 LICOS, inducible T-cell co-stimulator ligand, ICOSLG, ICOS-L, ICOSL, ICOS ligand, GL50, CD275, B7RP-1, B7RP1, B7-h2, B7H2
Anti-ICOS ligand Antibody-APC (1W488) 是一种 APC-conjugated Mouse 抗体，靶向 ICOS ligand。Anti-ICOS ligand Antibody-APC (1W488) 可用于 FCM。
Anti-ICOS ligand Antibody-APC (1W488)
331 Anti-ICOS ligand Antibody-APC (1W488)
还可以产品编号 TMAY-01901A 别名 LICOS, inducible T-cell co-stimulator ligand, ICOSLG, ICOS-L, ICOSL, ICOS ligand, GL50, CD275, B7RP-1, B7RP1, B7-h2, B7H2
Anti-ICOS ligand Antibody-APC (1W488) 是一种 APC-conjugated Mouse 抗体，靶向 ICOS ligand。Anti-ICOS ligand Antibody-APC (1W488) 可用于 FCM。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 25 T | ¥ 680 | 5日内发货 | |
| 100 T | ¥ 1,485 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-ICOS ligand Antibody-APC (1W488) is a APC-conjugated Mouse antibody targeting ICOS ligand. Anti-ICOS ligand Antibody-APC (1W488) can be used in FCM. |
| 别名 | LICOS, inducible T-cell co-stimulator ligand, ICOSLG, ICOS-L, ICOSL, ICOS ligand, GL50, CD275, B7RP-1, B7RP1, B7-h2, B7H2 |
| Ig Type | Mouse IgG1 |
| 克隆号 | 1W488 |
| 交叉反应 | Human |
| 验证活性 | Flow cytometric analysis of ICOSLG(CD275) expression on RPMI8226 cells. |
| 应用 | FCM |
| 推荐剂量 | 5 μl/Test, 0.1 mg/ml |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human ICOS Ligand / B7-H2 (rh ICOS Ligand / B7-H2; TMPY-01672; NP_056074.1; Met1-Ser258) and conjugated with APC under optimum conditions, the unreacted APC was removed. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | PBS solution containing 0.5% BSA and 0.09% sodium azide |
| 研究背景 | Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmembrane glycoprotein with extracellular IgV and IgC domains and binds to ICOS on activated T cells, thus delivers a positive costimulatory signal for optimal T cell function. The structural features of ICOSL are crucial for its costimulatory function. The present study shows that ICOSL displays a marked oligomerization potential, resembling more like B7-1 than B7-2. B7-H2-dependent signaling may play an active role in a proliferative response rather than in cytokine and chemokine production. The CD28/B7 and ICOS/B7-H2 pathways are both critical for costimulating T cell immune responses. Deficiency in either pathway results in defective T cell activation, cytokine production, and germinal center formation.Cancer ImmunotherapyCo-stimulatory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint Detection: AntibodiesImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint Detection: FCM AntibodiesImmune Checkpoint Detection: WB AntibodiesImmune Checkpoint TargetsImmunotherapyTargeted Therapy |
| 偶联 | APC |
| 其他可选修饰符 | Unconjugated/FITC/PE |
| 可提供抗体种类 | 4 |
| 免疫原 | Recombinant Protein: Human ICOS Ligand / B7-H2 protein (TMPY-01672) |
| 抗原种属 | Human |
| 研究领域 | Cancer Drug Targets |
存储&运输
| 储存方式 | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
| 运输方式 | Shipping with blue ice. |
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