Carbacyclin

Name: Carbacyclin
Brand: TargetMol
SKU: T10673
Rating: 4.5 (1 reviews)

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产品编号 T10673Cas号 69552-46-1

别名 Carbaprostacyclin, Carba-PGI2

Carbacyclin, a PGI2 analog, is a prostacyclin (PGI2) receptor agonist and vasodilator with potent inhibitory platelet aggregation.

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产品编号 T10673 别名 Carbaprostacyclin, Carba-PGI2Cas号 69552-46-1

Carbacyclin, a PGI2 analog, is a prostacyclin (PGI2) receptor agonist and vasodilator with potent inhibitory platelet aggregation.

规格	价格	库存	数量
100 μg	待估	35日内发货
500 μg	待估	35日内发货

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产品介绍

生物活性

产品描述	Carbacyclin, a PGI2 analog, is a prostacyclin (PGI2) receptor agonist and vasodilator with potent inhibitory platelet aggregation.
体外活性	Carbacyclin acts as an inhibitor of platelet aggregation induced by ADP or collagen in vitro[2]. Carbacyclin activates CPT-1 mRNA expression through PPARδ, independent of the IP receptor signaling pathway. Carbacyclin (0.02 μM to 20 μM) activates the IP receptor signaling pathway via PKA, and such an effect is inhibited by H-89, a PKA inhibitor. Carbacyclin (0.02-80 μM) increases PPRE promoter activity via PPARδ independent of the IP receptor signaling pathway in cardiomyocytes [3].
体内活性	Carbacyclin is 0.03 times as active as prostacyclin on inhibiting platelet aggregation in human, rabbit, or dog plasma [2]. In the murine heart, Carbacyclin (100 μg, i.p.) induces CPT-1 mRNA expression [3].
别名	Carbaprostacyclin, Carba-PGI2