Name: Carbacyclin
Brand: TargetMol
SKU: T10673
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

100 μg

¥ 2,330

35日内发货

500 μg

¥ 3,870

35日内发货

生物活性

产品描述	Carbacyclin, a PGI2 analog, is a prostacyclin (PGI2) receptor agonist and vasodilator with potent inhibitory platelet aggregation.
体外活性	Carbacyclin acts as an inhibitor of platelet aggregation induced by ADP or collagen in vitro[2]. Carbacyclin activates CPT-1 mRNA expression through PPARδ, independent of the IP receptor signaling pathway. Carbacyclin (0.02 μM to 20 μM) activates the IP receptor signaling pathway via PKA, and such an effect is inhibited by H-89, a PKA inhibitor. Carbacyclin (0.02-80 μM) increases PPRE promoter activity via PPARδ independent of the IP receptor signaling pathway in cardiomyocytes [3].
体内活性	Carbacyclin is 0.03 times as active as prostacyclin on inhibiting platelet aggregation in human, rabbit, or dog plasma [2]. In the murine heart, Carbacyclin (100 μg, i.p.) induces CPT-1 mRNA expression [3].
别名	Carbaprostacyclin, Carba-PGI2

化学信息

分子量	350.49
分子式	C₂₁H₃₄O₄
CAS No.	69552-46-1
Smiles	C(=C/[C@H](CCCCC)O)\[C@@H]1[C@@]2([C@@](C/C(=C\CCCC(O)=O)/C2)(C[C@H]1O)[H])[H]
密度	1.177 g/cm3

储存&溶解度

存储	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. 实际储存温度请以COA为准

Carbacyclin