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Anti-Granzyme B Antibody (4I316)
还可以产品编号 TMAY-00660
Anti-Granzyme B Antibody (4I316) 是一种 Mouse 抗体，靶向 Granzyme B。Anti-Granzyme B Antibody (4I316) 可用于 ELISA,IHC-P。
Anti-Granzyme B Antibody (4I316)
Anti-Granzyme B Antibody (4I316)
还可以产品编号 TMAY-00660
Anti-Granzyme B Antibody (4I316) 是一种 Mouse 抗体，靶向 Granzyme B。Anti-Granzyme B Antibody (4I316) 可用于 ELISA,IHC-P。
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-Granzyme B Antibody (4I316) is a Mouse antibody targeting Granzyme B. Anti-Granzyme B Antibody (4I316) can be used in ELISA,IHC-P. |
| Ig Type | Monoclonal Mouse IgG2b |
| 克隆号 | 4I316 |
| 交叉反应 | Human |
| 验证活性 | 1. Immunochemical staining of human Granzyme B in human tonsil with mouse monoclonal antibody (1:60, formalin-fixed paraffin embedded sections). 2. Immunochemical staining of human Granzyme B in human spleen with mouse monoclonal antibody (1:60, formalin-fixed paraffin embedded sections). 3. Immunochemical staining of human Granzyme B in human lymph node with mouse monoclonal antibody (1:60, formalin-fixed paraffin embedded sections). |
| 应用 | ELISA,IHC-P |
| 推荐剂量 | ELISA: 1:1000-1:2000; IHC-P: 1:50-1:200 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Granzyme B (rhGranzyme B; TMPY-00817; NP_004122.1; Met 1-Tyr 247). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Granzyme B, also known as GZMB, is the most prominent member of the granzyme family of cell death-inducing serine proteases expressed in the granules of cytotoxic T lymphocytes (CTLs) and NK cells. Granzyme B enters the target cells depending on another membrane-binding granule protein, perforin, results in the activation of effector caspases and mitochondrial depolarization through caspase-dependent and -independent pathways, and consequently induces rapid cell apoptosis. Over 3 substrates of GZMB have been identified including the key substrate caspase-3, ICAD, and Bid. GZMB is suggested to protect the host by lysing cells bearing on their surface 'nonself' antigens such as bacterial and viral infected-cells and tumor cells and accordingly plays an essential role in immunosurveillance. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human Granzyme B protein (TMPY-00817) |
| 抗原种属 | Human |
| 研究领域 | Serine Proteases and Regulators |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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