规格

价格

库存

数量

2 mg

¥ 1,890

5日内发货

5 mg

¥ 2,890

5日内发货

25 mg

¥ 9,620

8-10周

50 mg

¥ 12,500

8-10周

100 mg

¥ 17,500

8-10周

1 mL x 10 mM (in DMSO)

¥ 2,830

5日内发货

生物活性

产品描述	Integrin Antagonists 27 is a small molecule integrin αvβ3 antagonist. It has a binding affinity of 18 nM and as a novel anticancer agent.
体外活性	Integrin Antagonists 27 is treated with a panel of cancer cell lines. Which include breast cancer cell line MDA-MB-435, breast cancer cell lines MCF-7, mouse fibroblast NIH3T3, ovarian cancer cell line HEY, lung cancer cell line NCI-H1975. It has an IC50 of >20 uM.

化学信息

分子量	444.44
分子式	C₂₄H₂₀N₄O₅
CAS No.	593274-97-6
Smiles	Cc1ccc(NC(=O)CN2C(=O)N\C(=C/c3cccn3-c3cccc(c3)C(O)=O)C2=O)cc1
密度	1.38 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 100 mg/mL (225 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (7.43 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2500 mL	11.2501 mL	22.5002 mL	112.5011 mL
5 mM	0.4500 mL	2.2500 mL	4.5000 mL	22.5002 mL
10 mM	0.2250 mL	1.1250 mL	2.2500 mL	11.2501 mL
20 mM	0.1125 mL	0.5625 mL	1.1250 mL	5.6251 mL
50 mM	0.0450 mL	0.2250 mL	0.4500 mL	2.2500 mL
100 mM	0.0225 mL	0.1125 mL	0.2250 mL	1.1250 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

Integrin Antagonists 27

Integrin Antagonists 27

产品介绍

计算器

体内实验配液计算器

剂量转换

引用文献

关键词

Integrin Antagonists 27

Integrin Antagonists 27