Name: Minocycline
Brand: TargetMol
SKU: T131626
Price: 6299 CNY
Availability: InStock
Rating: 5 (10 reviews)

规格

价格

库存

数量

5 mg

¥ 6,299

In stock

产品介绍

生物活性

产品描述	Minocycline is a broad-spectrum and highly lipophilic tetracycline antibiotic with the advantages of being orally administrable and able to penetrate the blood-brain barrier. It binds to the 30S ribosomal subunit to inhibit protein synthesis, is effective against both Gram-positive and Gram-negative bacteria, and also has neuroprotective, anti-inflammatory, and antioxidant effects.
体外活性	Minocycline (0-100 μM，24-72 小时) 处理卵巢癌细胞系 (OVCAR-3、SKOV-3 和 A2780) ，观察其对细胞增殖的影响。结果：Minocycline可以抑制OVCAR-3、SKOV-3 和 A2780)的增殖以及克隆形成活性。[1]
体内活性	方法：Minocycline (0-30 mg/kg，口服，每日一次，持续 4 周) 处理OVCAR-3肿瘤异种移植雌性裸鼠，研究其对小鼠体内肿瘤的抑制作用。结果：Minocycline可抑制雌性裸鼠体内 OVCAR-3 肿瘤的生长。[1]
别名	米诺环素

化学信息

分子量	457.48
分子式	C₂₃H₂₇N₃O₇
CAS No.	10118-90-8
Smiles	O[C@]12[C@]([C@H](N(C)C)C(O)=C(C(N)=O)C1=O)(C[C@]3(C(=C2O)C(=O)C=4C(C3)=C(N(C)C)C=CC4O)[H])[H]

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 20.00 mg/mL (43.72 mM), Sonication is recommended.

溶液配制表

DMSO

体内实验配液计算器