Name: FGF-4 Protein, Human, Recombinant
Brand: TargetMol
SKU: TMPY-05004
Price: 335 CNY
Availability: InStock
Rating: 5 (10 reviews)

规格

价格

库存

数量

5 μg

¥ 335

现货

10 μg

¥ 535

现货

20 μg

¥ 875

现货

50 μg

¥ 1,730

现货

100 μg

¥ 2,930

现货

200 μg

¥ 5,190

现货

生物活性

产品描述	FGF (fibroblast growth factor) signalling is known to be required for many aspects of mesoderm formation and patterning during Xenopus development and has been implicated in regulating genes required for the specification of both blood and skeletal muscle lineages. Fibroblast growth factor 4 (FGF4) signaling induces differentiation from embryonic stem cells (ESCs) via the phosphorylation of downstream molecules such as mitogen-activated protein kinase/extracellular signal-related kinase (MEK) and extracellular signal-related kinase 1/2 (ERK1/2). Fibroblast Growth Factor 4 (FGF-4) could not only increase the proliferation of bone marrow mesenchymal stem cells (BMSCs), but also induce BMSCs into hepatocyte-like cells in vitro. FGF4 transduced BMSCs contributed to liver regeneration might by the transplanted microenvironment. The FGF4-bFGF BMSCs thus can enhance the survival of the transplanted cells, diminish myocardial fibrosis, promote myocardial angiogenesis, and improve cardiac functions.
生物活性	Measured in a cell proliferation assay using Balb/c 3T3 mouse fibroblasts. The ED50 for this effect is typically 0.04-0.2 ng/mL.
研究背景	FGF (fibroblast growth factor) signalling is known to be required for many aspects of mesoderm formation and patterning during Xenopus development and has been implicated in regulating genes required for the specification of both blood and skeletal muscle lineages. Fibroblast growth factor 4 (FGF4) signaling induces differentiation from embryonic stem cells (ESCs) via the phosphorylation of downstream molecules such as mitogen-activated protein kinase/extracellular signal-related kinase (MEK) and extracellular signal-related kinase 1/2 (ERK1/2). Fibroblast Growth Factor 4 (FGF-4) could not only increase the proliferation of bone marrow mesenchymal stem cells (BMSCs), but also induce BMSCs into hepatocyte-like cells in vitro. FGF4 transduced BMSCs contributed to liver regeneration might by the transplanted microenvironment. The FGF4-bFGF BMSCs thus can enhance the survival of the transplanted cells, diminish myocardial fibrosis, promote myocardial angiogenesis, and improve cardiac functions.
种属	Human
表达系统	E. coli
标签	Tag Free
蛋白编号	P08620
蛋白构建	A DNA sequence encoding the human FGF4 (NP_001998.1) (Ser54-Leu206) was expressed. Predicted N terminal: Met
蛋白纯度	≥ 95 % as determined by SDS-PAGE. ≥ 95 % as determined by SEC-HPLC.
蛋白性状	Lyophilized powder
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	Reconstituted with sterile deionized water to 0.25 mg/mL. Reconstitution conditions may vary depending on the lot.
别名	K-FGF, KFGF, HSTF1, HST-1, HST, HBGF-4, fibroblast growth factor 4
内毒素	< 10 EU/mg of the protein.