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顶部生物活性储存和溶解信息计算器

Anti-Granzyme B Antibody (6G558)

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产品编号 TMAC-01707

Anti-Granzyme B Antibody (6G558) 是一种 Mouse 抗体，靶向 Granzyme B。Anti-Granzyme B Antibody (6G558) 可用于 IF,IHC-P,IP,WB。

Anti-Granzyme B Antibody (6G558)

Anti-Granzyme B Antibody (6G558)

一键复制产品信息
Rating icon 还可以
产品编号 TMAC-01707

Anti-Granzyme B Antibody (6G558) 是一种 Mouse 抗体，靶向 Granzyme B。Anti-Granzyme B Antibody (6G558) 可用于 IF,IHC-P,IP,WB。

规格价格库存数量
50 μL
¥ 1,995
5日内发货
100 μL
¥ 2,995
5日内发货
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产品介绍

生物活性
产品描述
Anti-Granzyme B Antibody (6G558) is a Mouse antibody targeting Granzyme B. Anti-Granzyme B Antibody (6G558) can be used in IF,IHC-P,IP,WB.
克隆号
6G558
交叉反应
Human,Mouse,Rat
验证活性
1. Western blot analysis of granzyme B expression in non-transfected (A) and human granzyme B transfected (B) 293T whole cell lysates.
2. Immunoperoxidase staining of formalin fixed, paraffin-embedded human spleen tissue showing cytoplasmic staining of cells in red pulp.
verifiedActivityverifiedActivity
应用IFIHC-PIPWB
推荐剂量
WB: 1:100-1000; IP: 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate); IF: 1:50-1:200; IHC-P: 1:50-500
抗体种类
Monoclonal
宿主来源Mouse
构建方式Hybridoma Monoclonal Antibody
纯化方式ProA affinity purified
性状Liquid
缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
研究背景Granzyme A and granzyme B are serine proteases that mediate apoptotic signaling in cytotoxic T lymphocytes (CTL) and natural killer (NK) cells. Both granzyme A and granzyme B are synthesized as inactive proenzymes, and they are stored within cytolytic granules and released by effector cells during degranulation. In activated CTLs, granzyme A and granzyme B are processed and activated by cathepsin C, and they then function to induce apoptosis by two distinct pathways. Granzyme B proteolytically cleaves and activates members of the caspase family of cysteine proteases, including caspase-3, caspase-6, caspase-7 and caspase-9. When cleaved, these caspases assemble into active holoenzymes that then mediate apoptosis through a defined proteolytic cascade involving nuclear lamins and PARP (poly ADP ribose polymerase). Granzyme A mediates the activation of apoptosis by inducing single-strand DNA breaks, membrane perturbation and nuclear condensations in an alternative pathway that is independent from caspase activation or the caspase proteolytic cascade.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Amino acids 1-247 representing full length granzyme B of human origin
抗原种属
human
Uniprot ID
P10144
化学信息
分子量Theoretical: 32 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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关键词

T-cell serine protease 1-3ESECTLymphocyte proteaseHuman lymphocyte protein (HLP)HLPGZMBGRBGranzymeBGranzyme-2Granzyme2Granzyme BFragmentin-2Fragmentin2Cytotoxic T-lymphocyte proteinase 2 (Lymphocyte protease)CTSGL1CTSGL 1CTLA-1CTLA1CTLA 1CSPBCGL1CGL 1Cathepsin G-like 1 (CTSGL1)C11C 11

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