Name: Q134R
Brand: TargetMol
SKU: T35892
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

2 mg

¥ 1,570

5日内发货

5 mg

¥ 2,660

5日内发货

25 mg

¥ 9,160

5日内发货

50 mg

¥ 11,900

5日内发货

100 mg

¥ 17,500

5日内发货

1 mL x 10 mM (in DMSO)

¥ 3,180

5日内发货

生物活性

产品描述	Q134R, a neuroprotective derivative of hydroxyquinoline, effectively inhibits nuclear factor of activated T-cell (NFAT) signaling and possesses the ability to cross the blood-brain barrier. This compound shows promise for research into Alzheimer’s disease (AD) and aging-related disorders[1].
体外活性	Q134R (1-10 μM) suppresses NFAT signaling, without inhibiting calcineurin activity. Q134R partially inhibits NFAT activity in primary rat astrocytes, but does not prevent calcineurin-mediated dephosphorylation of a non-NFAT target, either in vivo, or in vitro[1].
体内活性	Q134R (4 mg/kg; orally gavage; twice per day; for 7 days) treatment improves cognitive function in rodent models of AD‐like pathology[1].
别名	Q134R