AZD2906

Name: AZD2906
Brand: TargetMol
SKU: T14374
Rating: 4.5 (1 reviews)

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产品编号 T14374Cas号 1034148-15-6

AZD2906, a selective glucocorticoid receptor (GR) agonist, demonstrates inhibitory concentrations (IC50s) of 2.2 nM in human GR, 0.3 nM in rat peripheral blood mononuclear cells (PBMC), 41.6 nM in human whole blood, and 7.5 nM in rat whole blood, respectively[1]. Additionally, it induces an increase in micronucleated immature erythrocytes within rat bone marrow.

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AZD2906

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产品编号 T14374Cas号 1034148-15-6

规格	价格	库存
5 mg	¥ 3,730	6-8周
25 mg	¥ 10,600	6-8周
50 mg	¥ 13,800	6-8周
100 mg	¥ 17,500	6-8周
1 mL x 10 mM (in DMSO)	¥ 4,120	6-8周

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产品介绍

生物活性

产品描述	AZD2906, a selective glucocorticoid receptor (GR) agonist, demonstrates inhibitory concentrations (IC50s) of 2.2 nM in human GR, 0.3 nM in rat peripheral blood mononuclear cells (PBMC), 41.6 nM in human whole blood, and 7.5 nM in rat whole blood, respectively[1]. Additionally, it induces an increase in micronucleated immature erythrocytes within rat bone marrow.
靶点活性	GR (human whole blood):41.6 nM, GR (rat whole blood):7.5 nM, GR (human PBMC):2.2 nM, GR (rat PBMC):0.3 nM
体外活性	AZD2906 is a selective glucocorticoid receptor (GR), with IC50s of 2.2, 0.3, 41.6 and 7.5 nM at GR in human, rat PBMC and human, rat whole blood, respectively[1].
体内活性	AZD2906 (5, 25, 50 mg/kg, p.o.) increases micronucleated immature erythrocytes (MIE) in the bone marrow of rats after treatment for 2 days[1]. AZD2906 (5, 25 mg/kg, p.o.) induces an accumulation of glycogen in the liver of rats. And it exhibits cortical lymphocytic atrophy of a moderate to marked degree in the thymus of rats[1].

化学信息

分子量	460.5
分子式	C₂₆H₂₅FN₄O₃
CAS No.	1034148-15-6
密度	1.33 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 125 mg/mL (271.44 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1716 mL	10.8578 mL	21.7155 mL	108.5776 mL
5 mM	0.4343 mL	2.1716 mL	4.3431 mL	21.7155 mL
10 mM	0.2172 mL	1.0858 mL	2.1716 mL	10.8578 mL
20 mM	0.1086 mL	0.5429 mL	1.0858 mL	5.4289 mL
50 mM	0.0434 mL	0.2172 mL	0.4343 mL	2.1716 mL
100 mM	0.0217 mL	0.1086 mL	0.2172 mL	1.0858 mL