BR102375 (Compound 18) (10 μM) increases gene expression levels relevant to PPARγ activation and enhances glucose uptake under insulin stimulation. BR102375 (10 nM, 100 nM, 1 μM; 6 days, 14 days) shows a concentration-dependent, insulin-sensitive effects on adipogenesis [1].

BR102375 has decent efficacy on the mouse diabetes model.BR102375 reveals significant suppressive effect on random blood glucose increase(75 mpk, p.o., bid), shows a decent effect on insulin resistance on the Oral glucose tolerance test (OGTT), and discloses similar findings in body weight gain almost identical to Pioglitazone [1].