L-159282 (3 mg/kg, p.o.) reduces blood pressure to normotensive (< 120 mm Hg) levels without causing reflex tachycardia in aortic coarcted (high renin) rats. In anesthetized chimpanzees, L-159282 (1 mg/kg, iv) completely inhibits the AII pressor response and remains 52% active at 24 hours, decreasing blood pressure to levels comparable to losartan (3 mg/kg, p.o.) and enalapril (3 mg/kg, p.o.) in this model[1].