规格

价格

库存

数量

1 mg

¥ 787

现货

5 mg

¥ 1,990

现货

10 mg

¥ 3,280

现货

25 mg

¥ 5,260

现货

50 mg

¥ 7,190

现货

100 mg

¥ 9,720

现货

1 mL x 10 mM (in DMSO)

¥ 2,970

现货

生物活性

产品描述	AP1867 (FK506-binding protein) is a synthetic FKBP12 F36V-directed ligand attached to 320 substituted tetrahydrooxazepines (THOXs). AP1867 (FK506-binding protein) was synthesized via combined liquid- and solid-phase methods employing sequential Mitsunobu displacements followed by ruthenium-mediated olefin metathesis to close seven-membered rings; the resin-bound THOX ligands were coupled to AP1867 in parallel, yielding candidate heterodimerizers that demonstrated membrane permeability and bioactivity in human fibrosarcoma cells, facilitating the study of targeted protein interactions and intracellular modulation.
体外活性	AP1867与野生型FKBP结合，其Kd值为67 nM[2]。
别名	AP-1867, AP 1867

化学信息

分子量	693.78
分子式	C₃₈H₄₇NO₁₁
CAS No.	195514-23-9
Smiles	[C@H](C(=O)N1[C@H](C(O[C@H](CCC2=CC(OC)=C(OC)C=C2)C3=CC(OCC(O)=O)=CC=C3)=O)CCCC1)(CC)C4=CC(OC)=C(OC)C(OC)=C4
密度	1.214 g/cm3 (Predicted)
颜色	White
物理性状	Solid

储存&溶解度

存储

keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度信息

DMSO: 80 mg/mL (115.31 mM), Sonication is recommeded.

体内实验配方

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (4.76 mM), Sonication is recommeded.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO