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NRG1 beta 1 Protein, Human, Recombinant

产品编号 TMPY-03010NRG1 beta 1 Protein, Human, Recombinant
NRG1 beta 1 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 26.8 kDa and the accession number is Q02297-6.
规格价格库存数量
10 μg
¥ 560
5日内发货
100 μg
¥ 2,940
5日内发货
1 mg
¥ 19,100
5日内发货
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产品信息

生物活性
Measured in a cell proliferation assay using MCF-7 cells. The ED50 for this effect is typically 2-10 ng/mL.
产品描述
NRG1 beta 1 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 26.8 kDa and the accession number is Q02297-6.
种属
Human
表达系统
HEK293 Cells
标签Tag Free
蛋白编号Q02297-6
别名
SMDF,NRG1-IT2,NRG1 β1,Neuregulin 1,NDF,MSTP131,MST131,HRGA,HRG1,HRG,HGL,Heregulin beta-1,GGF2,GGF,ARIA
蛋白构建
A DNA sequence encoding the N-terminal fragment (Ser 2-Lys 246) of human NRG1 isoform beta1 (Q02297-6) was expressed. Predicted N terminal: Ser 2
蛋白纯度
> 90 % as determined by SDS-PAGE
分子量26.8 kDa (predicted); 47.7 kDa (reducing condition, due to glycosylation)
内毒素< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法
A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储
It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式In general, Lyophilized powders are shipping with blue ice.
研究背景
Neuregulin 1 or NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. This growth factor was originally identified as a 44-kD glycoprotein that interacts with the NEU / ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. NRG1 is a trophic factor that has been implicated in neural development, neurotransmission, and synaptic plasticity. NRG1 has multiple isoforms that are generated by the usage of different promoters and alternative splicing of a single gene. Neuregulin 1 (NRG1) is essential for the development and function of multiple organ systems, and its dysregulation has been linked to diseases such as cancer and schizophrenia. NRG1 is a schizophrenia candidate gene and plays an important role in brain development and neural function. Schizophrenia is a complex disorder, with etiology likely due to epistasis.

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计算器

  • 复溶 计算器
  • 重组蛋白稀释 计算器
  • 比活力 计算器

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