Name: TT-OAD2
Brand: TargetMol
SKU: T13218
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

100 mg

待询

500 mg

待询

生物活性

产品描述	TT-OAD2 is a non-peptide agonist of the glucagon-like peptide-1 (GLP-1) receptor (EC50: 5 nM), with potential for diabetes treatment.
靶点活性	GLP1 receptor:(EC50)5 nM
体外活性	In HEK293A cells, TT-OAD2 (0-10 μM) inhibits GLP-1- and oxyntomodulin-mediated cAMP, calcium, pERK1/2 and β-arrestin responses in a concentration-dependent manner [1].
体内活性	In male human GLP-1 receptor knock-in and knockout mice, TT-OAD2 (3 mg/kg; intravenous injection)treatment induces plasma insulin in an acute IVGTT on humanized GLP-1R knock-in (KI) and GLP-1R knockout (KO) mice[1].

化学信息

分子量	929.75
分子式	C₅₀H₄₉Cl₄N₃O₆
CAS No.	2382719-60-8
Smiles	CC[C@@H](C1=CC=CC=C1)N2[C@@H](CC3=CC(OC[C@@](C4=CC=C(C=C4)OCC5=CC(Cl)=C(C=C5)Cl)([H])O6)=C6C=C3C2)C(N[C@H](C(O)=O)CC7=CC=C(C8=CC=NC(C)=C8C)C=C7)=O.Cl.Cl
密度	no data available

储存&溶解度

存储	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. 实际储存温度请以COA为准

TT-OAD2