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顶部生物活性储存和溶解信息计算器

Anti-FGFR2 Antibody (4V380)

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产品编号 TMAH-00431
别名 TK25, TK14, K-SAM, KGFR, JWS, FLJ98662, FGFR2 α (IIIb), FGFR2 α, FGFR2 alpha, FGF R2a, ECT1, CFD1, CEK3, CD332, BFR-1, BEK, BBDS

Anti-FGFR2 Antibody (4V380) 是一种抗体，靶向 FGFR2。Anti-FGFR2 Antibody (4V380) 可用于 ELISA, WB。

Anti-FGFR2 Antibody (4V380)

Anti-FGFR2 Antibody (4V380)

Rating icon 还可以
产品编号 TMAH-00431 别名 TK25, TK14, K-SAM, KGFR, JWS, FLJ98662, FGFR2 α (IIIb), FGFR2 α, FGFR2 alpha, FGF R2a, ECT1, CFD1, CEK3, CD332, BFR-1, BEK, BBDS

Anti-FGFR2 Antibody (4V380) 是一种抗体，靶向 FGFR2。Anti-FGFR2 Antibody (4V380) 可用于 ELISA, WB。

规格价格库存数量
50 μL
¥ 1,315
5日内发货
100 μL
¥ 2,185
5日内发货
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产品介绍

生物活性
产品描述
Anti-FGFR2 Antibody (4V380) is an antibody targeting FGFR2. Anti-FGFR2 Antibody (4V380) can be used in ELISA, WB.
别名TK25, TK14, K-SAM, KGFR, JWS, FLJ98662, FGFR2 α (IIIb), FGFR2 α, FGFR2 alpha, FGF R2a, ECT1, CFD1, CEK3, CD332, BFR-1, BEK, BBDS
Ig Type
Rabbit IgG
克隆号
4V380
交叉反应
Human, Mouse, Rat
验证活性
Western Blot
-Positive WB detected in: Rat Brain whole cell lysate, Rat Lung whole cell lysate, Mouse Brain whole cell lysate
-All lanes: FGFR2 Antibody at 1:1000
-Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution
-Predicted band size: 93, 87, 93, 77, 92, 89, 86, 29, 80, 93, 97, 92, 41, 80, 80, 77, 80 kDa
-Observed band size: 145 kDa
应用
ELISA, WB
推荐剂量
WB:1:500-1:5000.
抗体种类
Monoclonal
亚细胞定位Cell membrane; Single-pass type I membrane protein. Golgi apparatus. Cytoplasmic vesicle. Note=Detected on osteoblast plasma membrane lipid rafts. After ligand binding, the activated receptor is rapidly internalized and degraded.; [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Note=After ligand binding, the activated receptor is rapidly internalized and degraded.; [Isoform 3]: Cell membrane; Single-pass type I membrane protein. Note=After ligand binding, the activated receptor is rapidly internalized and degraded.; [Isoform 8]: Secreted.; [Isoform 13]: Secreted.
构建方式Recombinant Antibody
纯化方式Affinity-chromatography
性状Liquid
缓冲液Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
研究背景Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
A synthetic peptide: Human FGFR2
抗原种属
Human
基因ID
2263
Uniprot ID
研究领域
Neuroscience, Cancer, Cardiovascular, Developmental biology, Signal transduction, Stem cells
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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关键词

TK-25TK-14TK 25TK 14FLJ-98662FLJ 98662ECT-1ECT 1CFD-1CFD 1CEK-3CEK 3CD-332CD 332BFR1BFR 1

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