Permethrin

Name: Permethrin
Brand: TargetMol
SKU: T1332
Price: 284 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.54%

货号 T1332Cas号 52645-53-1

别名 氯菊酯, Transpermethrin, Pounce, NRDC-143, Ambush

Permethrin (NRDC-143) 是一种拟除虫菊酯类杀虫剂，常用于治疗虱子感染和疥疮。

Permethrin

一键复制产品信息

很棒

纯度: 99.54%

货号 T1332 别名 氯菊酯, Transpermethrin, Pounce, NRDC-143, AmbushCas号 52645-53-1

Permethrin (NRDC-143) 是一种拟除虫菊酯类杀虫剂，常用于治疗虱子感染和疥疮。

规格	价格	库存
50 mg	¥ 284	现货
100 mg	¥ 415	现货
500 mg	¥ 671	5日内发货
1 mL x 10 mM (in DMSO)	¥ 460	现货

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产品介绍

Permethrin AI Summary

Permethrin exhibits a wide spectrum of bioactivities with significant parasiticidal, insecticidal, and antifeedant properties. It demonstrates potent parasiticidal activity against Rhipicephalus sanguineus with an LD50 of 0.14 µg per tick and shows strong insecticidal effects against various insect species such as Periplaneta americana, Ascia monuste orseis, Sitophilus zeamais, and Acanthoscelides obtectus, with mortality rates ranging from 17.5% to 100%. The compound also inhibits feeding in Tineola bisselliella and Anthrenocerus australis larvae at a concentration of 0.01% w/w, leading to substantial wool weight loss. In assays, it exhibits mosquito larvicidal activity against Culex quinquefasciatus with LC50 values of 0.005 ppm and 0.16 ppm for susceptible and resistant strains, respectively. Permethrin shows a high lipophilicity with a log P value of 7.38, indicating a strong affinity for lipid environments. It also has a high octanol-water partition coefficient (log KOW = 6.1), suggesting potential for bioaccumulation in aquatic environments. The compound is active in a variety of receptor and enzyme interactions, displaying both agonist and antagonist activities and interacting with receptors such as HRH2, BDKRB2, GHSR, and AGTR1. It is also effective against first-instar larvae of Cheumatopsyche brevilineata and Daphnia magna, with higher toxicity toward the former. However, it exhibits no bioactivity related to liver injury or hepatic side effects based on DILIps assessments, with HepSE scores reported as 0.0. While strong contact toxicity is observed against adult Tetragonisca angustula, adult Solenopsis saevissima, and second-instar larvae of Tuta absoluta, the compound demonstrates high selectivity for particular pest control strategies. In therapeutic contexts, Permethrin shows promise in various biochemical pathways, indicating potential as a treatment for conditions such as Ataxia-Telangiectasia. Its potency ranges from 1.4 nM to above 420,000 nM in diverse bioassays, including those targeting Lamin A splicing, TDP1, histone lysine methyltransferases, and others. It also impacts liver enzyme activity, increasing levels of composite activity markers like SGOT, SGPT, and LDH. Overall, Permethrin is a versatile agent with significant bioactivity across multiple domains..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Permethrin (NRDC-143) is a pyrethroid insecticide commonly used in the treatment of LICE INFESTATIONS and SCABIES.
别名	氯菊酯, Transpermethrin, Pounce, NRDC-143, Ambush

化学信息

分子量	391.29
分子式	C₂₁H₂₀Cl₂O₃
CAS No.	52645-53-1
Smiles	CC1(C)[C@@H](C=C(Cl)Cl)C1C(=O)OCc1cccc(Oc2ccccc2)c1
密度	1.19

储存&溶解度

存储

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 250 mg/mL (638.91 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.11 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5556 mL	12.7782 mL	25.5565 mL	127.7825 mL
5 mM	0.5111 mL	2.5556 mL	5.1113 mL	25.5565 mL
10 mM	0.2556 mL	1.2778 mL	2.5556 mL	12.7782 mL
20 mM	0.1278 mL	0.6389 mL	1.2778 mL	6.3891 mL
50 mM	0.0511 mL	0.2556 mL	0.5111 mL	2.5556 mL
100 mM	0.0256 mL	0.1278 mL	0.2556 mL	1.2778 mL