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Podoplanin Protein, Mouse, Recombinant (His)

产品编号 TMPY-02659

别名: T1a, T1-α, T1α, OTS-8, T1-alpha, podoplanin, Gp38, T1alpha, RANDAM-2

Podoplanin Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 13 kDa and the accession number is Q62011.

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Podoplanin Protein, Mouse, Recombinant (His)

规格	价格/CNY		货期	数量
100 μg	￥ 3,820		5日内发货

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参考文献

生物活性	Measured by its ability to bind recombinant CLEC1B-His/Biotin in a functional ELISA.
产品描述	Podoplanin Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 13 kDa and the accession number is Q62011.

种属	Mouse
表达系统	Baculovirus Insect Cells
标签	C-His
蛋白编号	Q62011
别名	T1a, T1-α, T1α, OTS-8, T1-alpha, podoplanin, Gp38, T1alpha, RANDAM-2
蛋白构建	The Mouse PDPN N-terminal fragment (NP_034459.2) (Met 1-Lys 133) was expressed，with a C-terminal polyhistidine tag.
蛋白纯度	> 92 % as determined by SDS-PAGE
分子量	13 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM Tris, 500 mM NaCl, pH 7.4, 10% gly. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Podoplanin, also known as PDPN, is a type-I integral membrane glycoprotein with diverse distribution in human tissues. The physiological function of this protein may be related to its mucin-type character. The homologous protein in other species has been described as a differentiation antigen and influenza-virus receptor. The specific function of this protein has not been determined. Alternatively spliced transcript variants encoding different isoforms have been identified.PDPN is a mucin-type glycoprotein negatively charged by extensive O-glycosylation and a high content of sialic acid, which expresses the adhesive property. It is selectively expressed in lymphatic endothelium as well as lymphangiomas, Kaposi sarcomas, and in a subset of angiosarcomas with probable lymphatic differentiation. PDPN may contribute to form odontoblastic fiber or function as the anchorage to the tooth development and in proliferating epithelial cells of cervical loop and apical bud. The intensity of podoplanin expression is negatively correlated with the expression of CD34 and factor VIII. Podoplanin would be useful as a diagnostic marker for epithelioid hemangioendothelioma in liver tumors.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

参考文献

1. Kimura, N. et al., 2005, Pathol Int. 55 (2): 83-86. 2. Ordóñez, N.G., 2006, Adv Anat Pathol. 13 (2): 83-88. 3. Wicki, A. et al., 2007, Br. J. Cancer. 96 (1): 1-5. 4. Fujii,T. et al., 2008, Mod Pathol. 21 (2): 125-130. 5. Sawa,Y. et al., 2008, Acta Histochem Cytochem. 41 (5):121-126. 6. Kaddu, S. et al., 2009, Am J Dermatopathol. 31 (2): 137-139.

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Keywords

Podoplanin Protein, Mouse, Recombinant (His) T1a T1-α T1α OTS8 OTS-8 T1-alpha podoplanin RANDAM2 RANDAM 2 OTS 8 Gp38 T1alpha RANDAM-2 recombinant recombinant-proteins proteins protein

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

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