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Anti-ADAM10 Antibody (2F207)
还可以产品编号 TMAH-00026
别名 RAK, Mammalian disintegrin metalloprotease, MADM, Kuzbanian protein homolog, Kuzbanian, Kuz, HsT18717, HsT 18717, Drosophila, CDw156, CD156c antigen, CD156c, CD 156c, ADAM metallopeptidase domain 10, ADAM 10, AD18, AD10, AD 10, A disintegrin and metalloproteinase domain 10, A disintegrin and metalloprotease domain 10
Anti-ADAM10 Antibody (2F207) 是一种抗体，靶向 ADAM10。Anti-ADAM10 Antibody (2F207) 可用于 ELISA, FC。
Anti-ADAM10 Antibody (2F207)
Anti-ADAM10 Antibody (2F207)
还可以产品编号 TMAH-00026 别名 RAK, Mammalian disintegrin metalloprotease, MADM, Kuzbanian protein homolog, Kuzbanian, Kuz, HsT18717, HsT 18717, Drosophila, CDw156, CD156c antigen, CD156c, CD 156c, ADAM metallopeptidase domain 10, ADAM 10, AD18, AD10, AD 10, A disintegrin and metalloproteinase domain 10, A disintegrin and metalloprotease domain 10
Anti-ADAM10 Antibody (2F207) 是一种抗体，靶向 ADAM10。Anti-ADAM10 Antibody (2F207) 可用于 ELISA, FC。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,300 | 5日内发货 | |
| 100 μL | ¥ 2,180 | 5日内发货 |
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抗原信息
| 产品描述 | Anti-ADAM10 Antibody (2F207) is an antibody targeting ADAM10. Anti-ADAM10 Antibody (2F207) can be used in ELISA, FC. |
| 别名 | RAK, Mammalian disintegrin metalloprotease, MADM, Kuzbanian protein homolog, Kuzbanian, Kuz, HsT18717, HsT 18717, Drosophila, CDw156, CD156c antigen, CD156c, CD 156c, ADAM metallopeptidase domain 10, ADAM 10, AD18, AD10, AD 10, A disintegrin and metalloproteinase domain 10, A disintegrin and metalloprotease domain 10 |
| Ig Type | Mouse IgG2a |
| 克隆号 | 2F207 |
| 交叉反应 | Human |
| 验证活性 | Overlay Peak curve showing Hela cells stained with TMAH-00026 (red line) at 1:400. The cells were fixed in 4% formaldehyde (15min) and permeated by 0.2% TritonX-100 for 10min. Then 10% normal goat serum was Incubated to block non-specific protein-protein interactions followed by the antibody (1µg/1*10^6 cells) for 45 min at 4°C. The secondary antibody used was FITC-conjugated Goat Anti-Mouse IgG(H+L) at 1/200 dilution for 35 min at 4°C. Isotype control antibody (green line) was mouse IgG1 (1µg/1*10^6 cells) used under the same conditions. Acquisition of >10, 000 events was performed. |
| 应用 | ELISA, FC |
| 推荐剂量 | FC:1:20-1:500. |
| 抗体种类 | Monoclonal |
| 亚细胞定位 | Cell membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, clathrin-coated vesicle. Cell projection, axon. Cell projection, dendrite. Cell junction, adherens junction. Cytoplasm. |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | Affinity-chromatography |
| 性状 | Liquid |
| 缓冲液 | Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. |
| 研究背景 | Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis. Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B. Mediates the proteolytic cleavage of LAG3, leading to release the secreted form of LAG3. Mediates the proteolytic cleavage of IL6R and IL11RA, leading to the release of secreted forms of IL6R and IL11RA. Enhances the cleavage of CHL1 by BACE1. Cleaves NRCAM. Cleaves TREM2, resulting in shedding of the TREM2 ectodomain. Involved in the development and maturation of glomerular and coronary vasculature. During development of the cochlear organ of Corti, promotes pillar cell separation by forming a ternary complex with CADH1 and EPHA4 and cleaving CADH1 at adherens junctions. May regulate the EFNA5-EPHA3 signaling. (Microbial infection) Promotes the cytotoxic activity of S.aureus hly by binding to the toxin at zonula adherens and promoting formation of toxin pores. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein: Human ADAM10 Protein |
| 抗原种属 | Human |
| 基因ID | 102 |
| Uniprot ID | |
| 研究领域 | Cancer, Cell biology, Signal transduction |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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