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Anti-Cyclin A1/2 Antibody (8Y584)

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Anti-Cyclin A1/2 Antibody (8Y584)
产品编号 TMAC-01025
别名 Cyclin-A2, Cyclin-A1, Cyclin-A, CT146, CCNA2, CCNA1, CCNA, CCN1

Anti-Cyclin A1/2 Antibody (8Y584) 是一种 Rabbit 抗体，靶向 Cyclin A1/2。Anti-Cyclin A1/2 Antibody (8Y584) 可用于 WB,IHC,IP。

Anti-Cyclin A1/2 Antibody (8Y584)

Anti-Cyclin A1/2 Antibody (8Y584)

Rating icon 还可以
Anti-Cyclin A1/2 Antibody (8Y584)
产品编号 TMAC-01025 别名 Cyclin-A2, Cyclin-A1, Cyclin-A, CT146, CCNA2, CCNA1, CCNA, CCN1

Anti-Cyclin A1/2 Antibody (8Y584) 是一种 Rabbit 抗体，靶向 Cyclin A1/2。Anti-Cyclin A1/2 Antibody (8Y584) 可用于 WB,IHC,IP。

规格价格库存数量
50 μL
¥ 1,480
5日内发货
100 μL
¥ 2,490
5日内发货
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产品介绍

生物活性
产品描述
Anti-Cyclin A1/2 Antibody (8Y584) is a Rabbit antibody targeting Cyclin A1/2. Anti-Cyclin A1/2 Antibody (8Y584) can be used in WB,IHC,IP.
别名Cyclin-A2, Cyclin-A1, Cyclin-A, CT146, CCNA2, CCNA1, CCNA, CCN1
Ig Type
IgG
克隆号
8Y584
交叉反应
Human
验证活性
1. Western blot analysis of Cyclin A1/A2 on different lysates using anti-Cyclin A1/A2 antibody at 1/1,000 dilution. Positive control: Lane 1: Hela, Lane 2: HepG2.
2. Immunohistochemical analysis of paraffin-embedded human colon cancer tissue using anti-Cyclin A1/A2 antibody. Counter stained with hematoxylin.
应用
WB
IHC
IP
推荐剂量
WB: 1:1000-2000; IHC: 1:50-200
抗体种类
Monoclonal
宿主来源Rabbit
构建方式Recombinant Antibody
纯化方式ProA affinity purified
性状Liquid
缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
研究背景The critical role that the family of regulatory proteins known as cyclins play in eukaryotic cell cycle regulation is well established. Cyclin A accumulates prior to cyclin B in the cell cycle, appears to be involved in control of S phase and has been shown to associate with cyclin-dependent kinase-2 (Cdk2). In addition, cyclin A has been implicated in cell transformation and is found in complexes with E1A, transcription factors DRTF1 and E2F, and retinoblastoma protein p110. A second form of cyclin A, named cyclin A1 because of its high sequence homology to Xenopus cyclin A1, is most highly expressed in germ cells. It has been proposed that cyclin A1 can associate with Cdk2, p39 and Cdc2 p34. Cyclin A2 is a member of the highly conserved cyclin family. Cyclins regulate CDK kinases and different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclin A2 is expressed in all tissues tested, in contrast to cyclin A1, which is present only in germ cells. The Cyclin A2 protein binds and activates CDC2 or CDK2 kinases, and thus promotes both cell cycle G1/S and G2/M transitions. Cyclin A2 also functions in the transition to DNA replication and synthesis phases of the cell cycle and is quickly destroyed as the cell moves into mitosis.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein
化学信息
分子量Theoretical: 52/49 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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