Name: GSK-4381562
Brand: TargetMol
SKU: T9901A-1473
Rating: 4.5 (1 reviews)

生物活性

产品描述	GSK-4381562 represents a highly specialized fully human monoclonal antibody specifically engineered to target the human PVR-related immunoglobulin domain-containing protein with exceptional binding affinity and selectivity, effectively facilitating the measurable blockade of the inhibitory interaction between PVRIG and its primary ligand PVRL2 across various preclinical experimental models to evaluate the restoration of anti-tumor cytotoxic responses during strictly monitored laboratory observation periods.
体外活性	在利用人癌细胞进行的 T 细胞活化实验中，GSK-4381562 (Anti-PVRIG) 阻断了 PVRIG/PVRL2 的相互作用，增强了 CD8+ T 细胞增殖和 IFN-gamma 分泌 [1]。
体内活性	在人源化小鼠肿瘤模型中，通过全身给药方式给予 GSK-4381562 (Anti-PVRIG) 显著抑制了肿瘤生长并增加了瘤内免疫细胞浸润 [1]。
反应种属	Human
应用	ELISA FACS Functional assay
抗体种类	Monoclonal
内毒素	<1.0 EU/mg

抗体信息

同型

IgG1

偶联与修饰

偶联	Unconjugated

抗原信息

Uniprot ID	Q6DKI7
靶点	PVRIG

储存&溶解度

存储	store at low temperature \| -20°C for 2 years, 4°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.

GSK-4381562