Name: EC0489
Brand: TargetMol
SKU: T13672
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

25 mg

待询

生物活性

产品描述	EC0489, Small molecule-drug conjugate (SMDC) ,a conjugate of folic acid and desacetyl vinblastine hydrazide, is a high-affinity ligand for the folate receptor (FR). Refractory or metastatic Tumor.
体外活性	FR-positive KB cells are highly sensitive to EC0489 with an IC50 of 5 nM.The affinity of EC0489 toward the folate receptor (FR) is approximately half of that of folic acid (relative affinity 0.50).
体内活性	EC0489 (2, 3, and 4 μmol/kg) has antitumor activity against mice KB tumor models in a dose-dependent manner.EC0489 has a favorable toxicology profile in Rats.

化学信息

分子量	2550.7
分子式	C₁₁₁H₁₅₆N₂₂O₄₃S₂
CAS No.	1096702-14-5
Smiles	[H][C@@]12N3CC[C@@]11c4cc(c(OC)cc4N(C)[C@@]1([H])[C@](O)([C@H](O)[C@]2(CC)C=CC3)C(=O)NNC(=O)OCCSSC[C@H](NC(=O)[C@H](CCC(=O)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(=O)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(=O)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)NC(=O)CC[C@H](NC(=O)c1ccc(NCc2c[nH]c3nc(N)nc(=O)c3n2)cc1)C(O)=O)C(O)=O)[C@]1(C[C@@]2([H])C[N@](C[C@](O)(CC)C2)CCc2c1[nH]c1ccccc21)C(=O)OC \|c:29\|
密度	1.66 g/cm3 (Predicted)