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Anti-Phospho-ATM (Ser1981) Antibody (3I272)
还可以产品编号 TMAH-00883
别名 telomere maintenance 1, Telomere fusion protein, TELO1, TEL1, Tefu, Serine/threonine-protein kinase ATM, Serine protein kinase ATM, Phospho-ATM (S1981), OTTHUMP00000232981, MGC74674, homolog, DKFZp781A0353, ATM serine/threonine kinase, ATE, ATDC, ATD, ATC, Ataxia telangiectasia mutated homolog, Ataxia telangiectasia mutated, ATA, AT1, A-T mutated homolog, A-T mutated, AT mutated
Anti-Phospho-ATM (Ser1981) Antibody (3I272) 是一种抗体，靶向 Phospho-ATM (Ser1981)。Anti-Phospho-ATM (Ser1981) Antibody (3I272) 可用于 ELISA, IF。
Anti-Phospho-ATM (Ser1981) Antibody (3I272)
Anti-Phospho-ATM (Ser1981) Antibody (3I272)
还可以产品编号 TMAH-00883 别名 telomere maintenance 1, Telomere fusion protein, TELO1, TEL1, Tefu, Serine/threonine-protein kinase ATM, Serine protein kinase ATM, Phospho-ATM (S1981), OTTHUMP00000232981, MGC74674, homolog, DKFZp781A0353, ATM serine/threonine kinase, ATE, ATDC, ATD, ATC, Ataxia telangiectasia mutated homolog, Ataxia telangiectasia mutated, ATA, AT1, A-T mutated homolog, A-T mutated, AT mutated
Anti-Phospho-ATM (Ser1981) Antibody (3I272) 是一种抗体，靶向 Phospho-ATM (Ser1981)。Anti-Phospho-ATM (Ser1981) Antibody (3I272) 可用于 ELISA, IF。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,300 | 5日内发货 | |
| 100 μL | ¥ 2,180 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-Phospho-ATM (Ser1981) Antibody (3I272) is an antibody targeting Phospho-ATM (Ser1981). Anti-Phospho-ATM (Ser1981) Antibody (3I272) can be used in ELISA, IF. |
| 别名 | telomere maintenance 1, Telomere fusion protein, TELO1, TEL1, Tefu, Serine/threonine-protein kinase ATM, Serine protein kinase ATM, Phospho-ATM (S1981), OTTHUMP00000232981, MGC74674, homolog, DKFZp781A0353, ATM serine/threonine kinase, ATE, ATDC, ATD, ATC, Ataxia telangiectasia mutated homolog, Ataxia telangiectasia mutated, ATA, AT1, A-T mutated homolog, A-T mutated, AT mutated |
| Ig Type | Rabbit IgG |
| 克隆号 | 3I272 |
| 交叉反应 | Human |
| 验证活性 | Immunofluorescence staining of Hela cells with TMAH-00883 at 1:100,counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG (H+L). |
| 应用 | ELISA, IF |
| 推荐剂量 | IF:1:20-1:200. |
| 抗体种类 | Monoclonal |
| 亚细胞定位 | Nucleus. Cytoplasmic vesicle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | Affinity-chromatography |
| 性状 | Liquid |
| 缓冲液 | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 研究背景 | Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FBXW7, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, UFL1, RAD9, UBQLN4 and DCLRE1C. May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Plays a role in replication-dependent histone mRNA degradation. Binds DNA ends. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation. Phosphorylates ATF2 which stimulates its function in DNA damage response. Phosphorylates ERCC6 which is essential for its chromatin remodeling activity at DNA double-strand breaks. |
| 偶联 | Unconjugated |
| 免疫原 | A synthetic peptide: Human Phospho-ATM (S1981) |
| 抗原种属 | Human |
| 基因ID | 472 |
| Uniprot ID | |
| 研究领域 | Epigenetics and Nuclear Signaling |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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