Thalifendine is one of the main products of Berberine demethylation catalyzed by CYP51 (secreted by intestinal flora), which has anti-inflammatory effects, reduces intestinal inflammation, improves intestinal barrier function, and reduces the production of inflammatory factors.

CYP2D6 (human liver microsomes, without preincubation):20.6 μM, CYP2D6 (human liver microsomes, after preincubation):6.49 μM

Thalifendine 在人肝微粒体中对 CYP2D6 表现出代谢依赖性抑制活性，预孵育后 IC₅₀ 从 20.6 μM 降至 6.49 μM，说明其可部分抑制 CYP2D6，但效力弱于黄连素[1]。