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Aceclidine

Name: Aceclidine
Brand: TargetMol
SKU: T19870
Price: 99 CNY
Availability: InStock
Rating: 5 (10 reviews)

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货号 T19870Cas号 827-61-2

别名 Quinuclidin-3-yl acetate, NSC-657843, NSC657843, NSC 657843, Glaucostat, 3-quinuclidinyl acetate, 3-Acetoxyquinuclidine, 1-azabicyclo[2.2.2]octan-3-yl acetate

Aceclidine (1-azabicyclo[2.2.2]octan-3-yl acetate) 是M3 mAChR 的调节剂，可用于有关通过降低眼内压治疗青光眼的研究。

Aceclidine

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货号 T19870 别名 Quinuclidin-3-yl acetate, NSC-657843, NSC657843, NSC 657843, Glaucostat, 3-quinuclidinyl acetate, 3-Acetoxyquinuclidine, 1-azabicyclo[2.2.2]octan-3-yl acetateCas号 827-61-2

Aceclidine (1-azabicyclo[2.2.2]octan-3-yl acetate) 是M3 mAChR 的调节剂，可用于有关通过降低眼内压治疗青光眼的研究。

规格	价格	库存	数量
200 mg	¥ 99	现货
1 mL x 10 mM (in DMSO)	¥ 113	现货

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产品介绍

Aceclidine AI Summary

Aceclidine exhibits a range of bioactivities primarily targeting muscarinic acetylcholine receptors and phosphoinositol metabolism. It demonstrates strong binding affinity to the muscarinic acetylcholine receptor M1, with an IC50 of 120 nM using [3H]oxotremorine-M radioligand in rat hippocampus membranes, and a lower binding affinity (IC50 of 2427 nM) with [3H]pirenzepine radioligand. At 100 µM, it stimulates phosphoinositol (PI) hydrolysis by 60.5% in A9 L cells transfected with M1 receptors, with an EC50 of 4466 nM. Additionally, it induces marked salivation or tremor in mice at a dose of 10 mg/kg (Score = 2.0). The compound also shows significant inhibition of [3H](R)-QNB binding to muscarinic receptors in rat brain membranes (IC50 of 510 nM) and an 80% agonist activity in PI metabolism assays in rat cerebral cortex slices. Against muscarinic receptor M3 in A9 L cells, it has an EC50 of 10000 nM and a maximum stimulation of 130%. Moreover, it demonstrates binding affinities with a Ki value of 16 nM for [3H]OXO-M in rat brain membranes and exhibits phosphoinositol stimulation responses of up to 300% in rat hippocampal slices with an EC50 of 21000 nM. Additionally, Aceclidine shows antiviral activity against SARS-CoV-2, inhibiting cytotoxicity of VERO-6 cells at moderate concentrations, with varied IC50 values greater than 19952.62 nM. In other assays, it inhibits SARS-CoV-2 3CL-Pro protease by approximately 31.5% at 20 µM. The compound has inhibitory effects on the malarial parasite plastid (IC50 = 4775.5 nM) and RGS4 (IC50 = 42.3 nM), and displays growth inhibition in various human tumor cell lines, with notable potency against the A498 Renal cell line (GI50 = 3451.44 nM). Furthermore, it shows bioactivity related to toxicity in Musca domestica and affinity for muscarinic acetylcholine receptors in Drosophila melanogaster..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Aceclidine (1-azabicyclo[2.2.2]octan-3-yl acetate) is a modulator of M3 mAChR and can be used in studies about treating glaucoma by reducing intraocular pressure.
别名	Quinuclidin-3-yl acetate, NSC-657843, NSC657843, NSC 657843, Glaucostat, 3-quinuclidinyl acetate, 3-Acetoxyquinuclidine, 1-azabicyclo[2.2.2]octan-3-yl acetate

化学信息

分子量	169.22
分子式	C₉H₁₅NO₂
CAS No.	827-61-2
Smiles	CC(=O)OC1CN2CCC1CC2
密度	1.0873 g/cm3 (Estimated)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

H2O: 10 mg/mL (59.09 mM), Sonication is recommended.

DMSO: Soluble

溶液配制表

H2O

	1mg	5mg	10mg	50mg
1 mM	5.9095 mL	29.5473 mL	59.0947 mL	295.4733 mL
5 mM	1.1819 mL	5.9095 mL	11.8189 mL	59.0947 mL
10 mM	0.5909 mL	2.9547 mL	5.9095 mL	29.5473 mL
20 mM	0.2955 mL	1.4774 mL	2.9547 mL	14.7737 mL
50 mM	0.1182 mL	0.5909 mL	1.1819 mL	5.9095 mL

计算器

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稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

Quinuclidin-3-yl Acetate M3 mAChR Aceclidine 3-quinuclidinyl Acetate 1-azabicyclo[2.2.2]octan-3-yl Acetate

Aceclidine

Aceclidine

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