SF-11 is a selective brain-permeable NPY Y2 receptor antagonist with IC50 value of 190 nM. A systematic study of the SAR of the hit molecule SF-11 can identify a selective and highly effective small molecule NPY Y2 receptor antagonist CYM 9484 . CYM 9484 is ten times more effective than the hit molecule SF-11. CYM 9484 is prepared by coupling α, α-diphenylpiperidino-4-methanol with various aryl isothiocyanates.