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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-Dnmt1 Polyclonal Antibody 2

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货号 TMAB-05256

Anti-Dnmt1 Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 Dnmt1。Anti-Dnmt1 Polyclonal Antibody 2 可用于 IHC-P,IHC-Fr,IF。

Anti-Dnmt1 Polyclonal Antibody 2

Anti-Dnmt1 Polyclonal Antibody 2

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Rating icon 还可以
货号 TMAB-05256

Anti-Dnmt1 Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 Dnmt1。Anti-Dnmt1 Polyclonal Antibody 2 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,160
5日内发货
100 μL
¥ 1,975
5日内发货
200 μL
¥ 2,795
5日内发货
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产品介绍

生物活性
产品描述
Anti-Dnmt1 Polyclonal Antibody 2 is a Rabbit antibody targeting Dnmt1. Anti-Dnmt1 Polyclonal Antibody 2 can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Human (predicted:Mouse,Rat,Dog,Pig,Cow,Horse,Sheep)
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Nucleus.
组织特异性Ubiquitous; highly expressed in fetal tissues, heart, kidney, placenta, peripheral blood mononuclear cells, and expressed at lower levels in spleen, lung, brain, small intestine, colon, liver, and skeletal muscle. Isoform 2 is less expressed than isoform 1.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Aberrant methylation patterns are associated with certain human tumors and developmental abnormalities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008].
抗原信息
免疫原
KLH conjugated synthetic peptide: human Dnmt1
抗原种属
Human
基因名称
DNMT1
基因ID
1786
蛋白名称
DNA(cytosine-5)-methyltransferase 1
Uniprot ID
P26358
功能
Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9.
化学信息
分子量Theoretical: 178 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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