规格

价格

库存

数量

2 mg

¥ 489

5日内发货

25 mg

¥ 4,310

5日内发货

50 mg

¥ 5,610

5日内发货

100 mg

¥ 10,300

5日内发货

生物活性

产品描述

SB-399885 hydrochloride is an antagonist of 5-HT6 receptor.

体内活性

SB-399885 hydrochloride 10 mg/kg significantly increases wakefulness (W) (F(3,15)=3.32, P<0.05) while slow wave sleep (SWS), rapid-eye-movement sleep (REMS) and the number of REM periods are reduced (F(3,15)=4.0, P<0.01; F(3,15)=3.14, P<0.05 and F(3,15)=2.62, P<0.05, respectively) Compare with the control vehicle . Analysis of sleep variables in 2-h blocks shows that SB-399885 hydrochloride 10 mg/kg increases W (F(3,15)=5.48, P<0.01) and reduces SWS (F(3,15)=5.42, P<0.01) and REMS (F(3,15)= 4.05, P<0.01) during the first 2-h period. SB-399885 hydrochloride 5 and 10 mg/kg augment light sleep over the first (F(3,15)=3.46,P<0.01 and F(3,15)= 3.65, P<0.01, respectively) and the second (F(3,15)=3.23, P<0.05 and F(3,15)=3.08, P<0.05, respectively) 2-h recording periods. SB-399885 hydrochloride 10 mg/kg significantly increases REMS latency (F(3,15)=3.60, P<0.01) and reduces the number of REM periods during the first 2-h of recording (F(3,15)=3.88, P<0.01).

化学信息

分子量	482.81
分子式	C₁₈H₂₂Cl₃N₃O₄S
CAS No.	402713-81-9
密度	1.31g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 125 mg/mL (258.9 mM), Sonication and heating are recommended.

体内实验配方

10% DMSO+90% Corn Oil: 3.3 mg/mL (6.83 mM), Sonication is recommeded.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0712 mL	10.3560 mL	20.7121 mL	103.5604 mL
5 mM	0.4142 mL	2.0712 mL	4.1424 mL	20.7121 mL
10 mM	0.2071 mL	1.0356 mL	2.0712 mL	10.3560 mL
20 mM	0.1036 mL	0.5178 mL	1.0356 mL	5.1780 mL
50 mM	0.0414 mL	0.2071 mL	0.4142 mL	2.0712 mL
100 mM	0.0207 mL	0.1036 mL	0.2071 mL	1.0356 mL