Microcystin-LR

Name: Microcystin-LR
Brand: TargetMol
SKU: T5204
Rating: 4.5 (1 reviews)

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产品编号 T5204Cas号 101043-37-2

别名 微囊藻毒素-LR, Toxin T 17 (Microcystis aeruginosa), Microcystin-LR, Microcystis aeruginosa, MC-LR, Cyanoginosin-LR

Microcystin-LR (Cyanoginosin-LR) 是一种蛋白磷酸酶 1 型和 2A 型的有效抑制剂，其 IC50值分别为 1.7 nM，0.04 nM。

Microcystin-LR

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产品编号 T5204 别名 微囊藻毒素-LR, Toxin T 17 (Microcystis aeruginosa), Microcystin-LR, Microcystis aeruginosa, MC-LR, Cyanoginosin-LRCas号 101043-37-2

Microcystin-LR (Cyanoginosin-LR) 是一种蛋白磷酸酶 1 型和 2A 型的有效抑制剂，其 IC50值分别为 1.7 nM，0.04 nM。

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产品介绍

生物活性

产品描述	Microcystin-LR (Cyanoginosin-LR) is a potent inhibitor of type 1 and type 2A protein phosphatases (PP1 and PP2A), with IC50s of 1.7 nM and 0.04 nM, respectively.
靶点活性	PP1:1.7 nM, PP2A:0.04 nM
体外活性	Microcystins are toxic molecules produced by cyanobacterial blooms due to water eutrophication[2]. Microcystin-LR proves to be a potent inhibitor of type 1 (IC50=1.7 nM) and type 2A (IC50= 0.04 nM) protein phosphatases. Microcystin-LR inhibits the activity of both type 1 and type 2A phosphatases >10-fold more potently than okadaic acid under the same conditions. Type 2A protein phosphatases in dilute mammalian cell extracts are found to be completely inhibited by 0.5 nM microcystin-LR while type 1 protein phosphatases are only slightly affected at this concentration[1].
别名	微囊藻毒素-LR, Toxin T 17 (Microcystis aeruginosa), Microcystin-LR, Microcystis aeruginosa, MC-LR, Cyanoginosin-LR

化学信息

分子量	995.17
分子式	C₄₉H₇₄N₁₀O₁₂
CAS No.	101043-37-2
Smiles	CC(C)C[C@@H](C(N[C@H]([C@H](C)C(N[C@@H](CCCNC(N)=N)C(N([C@@H](CCC(N(C)C(C(N[C@@H]1C)=O)=C)=O)C(O)=O)C(C(C)[C@H](/C=C/C(/C)=C/[C@H](C)[C@H](Cc2ccccc2)OC)N)=O)=O)=O)C(O)=O)=O)NC1=O
密度	1.29g/cm3

储存&溶解度

存储	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
溶解度信息	Ethanol: 0.5 mg/mL (0.50 mM), Sonication is recommended.