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SYM 2081

Name: SYM 2081
Brand: TargetMol
SKU: T16963
Price: 856 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.63%

货号 T16963Cas号 31137-74-3

SYM 2081 是一种特异性红藻氨酸受体激动剂，对 [3H]-红藻氨酸结合的 IC50 值为 35 nM。 SYM 2081 使肌肉去极化并降低 EPSP 振幅。

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SYM 2081

一键复制产品信息

很棒

纯度: 99.63%

货号 T16963Cas号 31137-74-3

SYM 2081 是一种特异性红藻氨酸受体激动剂，对 [3H]-红藻氨酸结合的 IC50 值为 35 nM。 SYM 2081 使肌肉去极化并降低 EPSP 振幅。

规格	价格	库存
1 mg	¥ 856	现货
5 mg	¥ 1,650	现货
10 mg	¥ 2,650	现货
25 mg	¥ 4,480	现货
50 mg	¥ 6,280	现货
100 mg	¥ 8,480	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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纯度: 99.63%

颜色: 白色

性状: Solid

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产品介绍

SYM 2081 AI Summary

SYM 2081 exhibits potent binding affinity for human ionotropic glutamate receptors kainate 1 (GluR5) and kainate 2 (GluR6) with Ki values of 3.0 nM and 10.0 nM, respectively. It demonstrates high selectivity towards GluR6 over GluR5, with a selectivity ratio of 3.3. It also shows significant inhibition of [3H]kainate binding to cortical membranes with an IC50 of 35.0 nM, while displaying negligible interaction with AMPA or NMDA receptors at concentrations higher than 7.0 nM. Additionally, SYM 2081 exhibits antagonist activity at GluR6, with an IC50 value of 4000.0 nM for the inhibition of glutamate-induced Ca2+ influx in HEK cells. In terms of metabotropic receptors, the compound shows a lower EC50 ratio against metabotropic glutamate receptor 1 compared to glutamate (4.6), and a higher EC50 ratio against metabotropic glutamate receptor 2 (23.0), indicating potential modulation of these receptors. Furthermore, it shows specific binding affinity to EAAT1, EAAT2, and EAAT3 transporters in HEK293 cells. SYM 2081 also demonstrates agonist activity in Xenopus oocytes, exhibiting high efficacy at GluK1(Q)1b mutant, moderate efficacy at GluK2 and GluK3 mutants, with varying EC50 values. In antiviral assays, it shows modest inhibition of SARS-CoV-2 induced cytotoxicity in Caco-2 and VERO-6 cells and inhibits the SARS-CoV-2 3CL-Pro protease by 18.64% at 20µM. Additionally, the compound inhibits human HDAC6, showing 40.16% inhibition with a commercial peptide substrate. Lastly, SYM 2081 affects cell viability in different cell lines, with varied impacts observed in HEK293T, U2OS, and human fibroblast cells, indicating a complex bioactivity profile across different cellular contexts..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	SYM 2081 is a specific kainate receptor agonist with an IC50 value of 35 nM for [3H]-kainate binding. SYM 2081 depolarizes the muscle and reduces the EPSP amplitude.
靶点活性	Kainate receptor:35 nM

化学信息

分子量	161.16
分子式	C₆H₁₁NO₄
CAS No.	31137-74-3
Smiles	[C@@H](C[C@@H](C(O)=O)N)(C(O)=O)C
密度	1.3482 g/cm3 (Estimated)

储存&溶解度

存储

溶解度信息

H2O: 45 mg/mL (279.23 mM), Sonication is recommended.

溶液配制表

H2O

	1mg	5mg	10mg	50mg
1 mM	6.2050 mL	31.0251 mL	62.0501 mL	310.2507 mL
5 mM	1.2410 mL	6.2050 mL	12.4100 mL	62.0501 mL
10 mM	0.6205 mL	3.1025 mL	6.2050 mL	31.0251 mL
20 mM	0.3103 mL	1.5513 mL	3.1025 mL	15.5125 mL
50 mM	0.1241 mL	0.6205 mL	1.2410 mL	6.2050 mL
100 mM	0.0621 mL	0.3103 mL	0.6205 mL	3.1025 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。