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Anti-Di-methyl-HIST1H3A (Lys4) Polyclonal Antibody 是一种 Rabbit 抗体,靶向 Di-methyl-HIST1H3A (Lys4)。Anti-Di-methyl-HIST1H3A (Lys4) Polyclonal Antibody 可用于 WB,ICC,IHC,FCM。
Anti-Di-methyl-HIST1H3A (Lys4) Polyclonal Antibody 是一种 Rabbit 抗体,靶向 Di-methyl-HIST1H3A (Lys4)。Anti-Di-methyl-HIST1H3A (Lys4) Polyclonal Antibody 可用于 WB,ICC,IHC,FCM。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
50 μL | ¥ 1,490 | 5日内发货 | |
100 μL | ¥ 2,240 | 5日内发货 |
产品描述 | Anti-Di-methyl-HIST1H3A (Lys4) Polyclonal Antibody is a Rabbit antibody targeting Di-methyl-HIST1H3A (Lys4). Anti-Di-methyl-HIST1H3A (Lys4) Polyclonal Antibody can be used in WB,ICC,IHC,FCM. |
别名 | Histone H3K4-dimethylated, H3K4me2, Di-methyl-HIST1H3A (K4), Di-Me-HIST1H3A (Lys4), Di-Me-HIST1H3A (K4), DiMe-H3K4 |
交叉反应 | Human,Mouse,Rat |
应用 | |
推荐剂量 | WB: 1: 1000 |
抗体种类 | Polyclonal |
宿主来源 | Rabbit |
构建方式 | Polyclonal Antibody |
纯化方式 | Immunogen affinity purified |
性状 | Liquid |
缓冲液 | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
研究背景 | The nucleosome, made up of DNA wound around eight core histone proteins (two each of H2A, H2B, H3, and H4), is the primary building block of chromatin. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for TP53BP1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120'. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are enriched in inactive X chromosome chromatin. |
偶联 | Unconjugated |
其他可选修饰符 | Methylated/Acetylated |
免疫原 | Peptide |
Uniprot ID |
分子量 | Theoretical: 17 kDa. |
储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
运输方式 | Shipping with blue ice. |
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