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Anti-Di-methyl-HIST1H3A (Lys4) Polyclonal Antibody 2

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Anti-Di-methyl-HIST1H3A (Lys4) Polyclonal Antibody 2
产品编号 TMAC-01933
别名 Histone H3K4-dimethylated, H3K4me2, Di-methyl-HIST1H3A (K4), Di-Me-HIST1H3A (Lys4), Di-Me-HIST1H3A (K4), DiMe-H3K4

Anti-Di-methyl-HIST1H3A (Lys4) Polyclonal Antibody 是一种 Rabbit 抗体,靶向 Di-methyl-HIST1H3A (Lys4)。Anti-Di-methyl-HIST1H3A (Lys4) Polyclonal Antibody 可用于 WB,ICC,IHC,FCM。

Anti-Di-methyl-HIST1H3A (Lys4) Polyclonal Antibody 2

Anti-Di-methyl-HIST1H3A (Lys4) Polyclonal Antibody 2

Rating icon 还可以
Anti-Di-methyl-HIST1H3A (Lys4) Polyclonal Antibody 2
产品编号 TMAC-01933 别名 Histone H3K4-dimethylated, H3K4me2, Di-methyl-HIST1H3A (K4), Di-Me-HIST1H3A (Lys4), Di-Me-HIST1H3A (K4), DiMe-H3K4

Anti-Di-methyl-HIST1H3A (Lys4) Polyclonal Antibody 是一种 Rabbit 抗体,靶向 Di-methyl-HIST1H3A (Lys4)。Anti-Di-methyl-HIST1H3A (Lys4) Polyclonal Antibody 可用于 WB,ICC,IHC,FCM。

规格价格库存数量
50 μL
¥ 1,490
5日内发货
100 μL
¥ 2,240
5日内发货
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产品介绍

生物活性
产品描述
Anti-Di-methyl-HIST1H3A (Lys4) Polyclonal Antibody is a Rabbit antibody targeting Di-methyl-HIST1H3A (Lys4). Anti-Di-methyl-HIST1H3A (Lys4) Polyclonal Antibody can be used in WB,ICC,IHC,FCM.
别名Histone H3K4-dimethylated, H3K4me2, Di-methyl-HIST1H3A (K4), Di-Me-HIST1H3A (Lys4), Di-Me-HIST1H3A (K4), DiMe-H3K4
交叉反应
Human,Mouse,Rat
应用
推荐剂量
WB: 1: 1000
抗体种类
Polyclonal
宿主来源Rabbit
构建方式Polyclonal Antibody
纯化方式Immunogen affinity purified
性状Liquid
缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
研究背景The nucleosome, made up of DNA wound around eight core histone proteins (two each of H2A, H2B, H3, and H4), is the primary building block of chromatin. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for TP53BP1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at 'Lys-120'. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are enriched in inactive X chromosome chromatin.
偶联与修饰
偶联
Unconjugated
其他可选修饰符
Methylated/Acetylated
抗原信息
免疫原
Peptide
Uniprot ID
化学信息
分子量Theoretical: 17 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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