Powder: -20°C for 3 years | In solvent: -80°C for 1 year
YNT-185 is a nonpeptide, selective agonist of the orexin type-2 receptor (OX2R), demonstrating EC50 values of 0.028 μM and 2.75 μM for OX2R and OX1R, respectively. Furthermore, YNT-185 effectively alleviates symptoms of narcolepsy-cataplexy in mouse models.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 595 | 现货 | ||
5 mg | ¥ 1,490 | 现货 | ||
10 mg | ¥ 2,390 | 现货 | ||
25 mg | ¥ 4,820 | 现货 | ||
50 mg | ¥ 7,730 | 现货 | ||
100 mg | ¥ 9,870 | 现货 |
产品描述 | YNT-185 is a nonpeptide, selective agonist of the orexin type-2 receptor (OX2R), demonstrating EC50 values of 0.028 μM and 2.75 μM for OX2R and OX1R, respectively. Furthermore, YNT-185 effectively alleviates symptoms of narcolepsy-cataplexy in mouse models. |
靶点活性 | OX2R:0.028(EC50), OX1R:2.75 μM(EC50) |
体内活性 |
YNT-185 (20-40 mg/kg; i.p.) enhances alertness in mice.[1]. In a dose-dependent manner, YNT-185 (300 nmol; i.c.v.) significantly extends wakefulness for a period of 3 hours, accompanied by a reduction in non-rapid eye movement (NREM) sleep duration, in wild-type mice but not in OXRDKO mice.[1] |
分子量 | 615.74 |
分子式 | C33H37N5O5S |
CAS No. | 1804978-81-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 62.0 mg/mL (90.0 mM)
H2O: Insoluble
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.6241 mL | 8.1203 mL | 16.2406 mL | 40.6016 mL |
5 mM | 0.3248 mL | 1.6241 mL | 3.2481 mL | 8.1203 mL | |
10 mM | 0.1624 mL | 0.812 mL | 1.6241 mL | 4.0602 mL | |
20 mM | 0.0812 mL | 0.406 mL | 0.812 mL | 2.0301 mL | |
50 mM | 0.0325 mL | 0.1624 mL | 0.3248 mL | 0.812 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
YNT-185 1804978-81-1 GPCR/G Protein Neuroscience OX Receptor YNT 185 YNT185 Inhibitor inhibitor inhibit