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Anti-Phospho-STAT1 (Tyr701) Polyclonal Antibody 2
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产品编号 TMAC-03869
别名 STAT1 (p-Y701), STAT1 (p-Tyr701), p-STAT1 (Y701), p-STAT1 (Tyr701)
Anti-Phospho-STAT1 (Tyr701) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-STAT1 (Tyr701)。Anti-Phospho-STAT1 (Tyr701) Polyclonal Antibody 可用于 WB,IHC。
Anti-Phospho-STAT1 (Tyr701) Polyclonal Antibody 2
Anti-Phospho-STAT1 (Tyr701) Polyclonal Antibody 2
还可以产品编号 TMAC-03869 别名 STAT1 (p-Y701), STAT1 (p-Tyr701), p-STAT1 (Y701), p-STAT1 (Tyr701)
Anti-Phospho-STAT1 (Tyr701) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-STAT1 (Tyr701)。Anti-Phospho-STAT1 (Tyr701) Polyclonal Antibody 可用于 WB,IHC。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,490 | 5日内发货 | |
| 100 μL | ¥ 2,230 | 5日内发货 |
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| 产品描述 | Anti-Phospho-STAT1 (Tyr701) Polyclonal Antibody is a Rabbit antibody targeting Phospho-STAT1 (Tyr701). Anti-Phospho-STAT1 (Tyr701) Polyclonal Antibody can be used in WB,IHC. |
| 别名 | STAT1 (p-Y701), STAT1 (p-Tyr701), p-STAT1 (Y701), p-STAT1 (Tyr701) |
| Ig Type | IgG |
| 交叉反应 | Human,Mouse,Rat |
| 验证活性 | 1. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using STAT1 (Phospho-Tyr701) Antibody TMAC-03869 (left) or the same antibody preincubated with blocking peptide (right). 2. Western blot analysis of extracts from MEF cells untreated or treated with interferon-ɤ (IFNɤ) using STAT1 (Phospho-Tyr701) Antibody TMAC-03869. 3. Western blot analysis of extracts from Hela cells, treated with IFNa or calf intestinal phosphatase (CIP), using STAT1 (Phospho-Tyr701) Antibody TMAC-03869. |
| 应用 | |
| 抗体种类 | Polyclonal |
| 宿主来源 | Rabbit |
| 构建方式 | Polyclonal Antibody |
| 纯化方式 | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
| 性状 | Liquid |
| 缓冲液 | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 研究背景 | Signal transducer and activator of transcription that mediates signaling by interferons (IFNs). Following type I IFN (IFN-a and IFN-beta) binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. |
| 偶联 | Unconjugated |
| 其他可选修饰符 | Phospho |
| 免疫原 | Peptide sequence around phosphorylation site of tyrosine 701 (T-G-Y(p)-I-K) derived from Human STAT1 |
| 抗原种属 | human |
| Uniprot ID |
| 分子量 | Actual: 84, 91 kDa. |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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