规格

价格

库存

数量

2 mg

¥ 1,950

5日内发货

25 mg

¥ 9,390

1-2周

50 mg

¥ 12,200

1-2周

100 mg

¥ 17,500

1-2周

生物活性

产品描述	BCX 1470 methanesulfonate inhibits the esterolytic activity of factor D and C1s (IC50: 96 nM and 1.6 nM), 3.4- and 200-fold better than that of trypsin, respectively.
靶点活性	C1s:1.6 nM , FD:96 nM , Trypsin:326 nM
体外活性	BCX 1470 methanesulfonate is an inhibitor serine protease. BCX 1470 blocks the esterolytic and hemolytic activities of the complement enzymes Cls and factor D in vitro.
体内活性	BCX 1470 methanesulfonate blocked the development of RPA-induced edema in the rat.

化学信息

分子量	398.48
分子式	C₁₅H₁₄N₂O₅S₃
CAS No.	217099-44-0
Smiles	CS(O)(=O)=O.NC(=N)c1cc2ccc(OC(=O)c3cccs3)cc2s1
密度	1.31g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 33.33 mg/mL (83.64 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2 mg/mL (5.02 mM), Sonication is recommeded.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO