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Anti-MLANA Polyclonal Antibody
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还可以货号 TMAB-01148
别名 Protein Melan-A, MLANA, Melanoma antigen recognized by T-cells 1, MART-1, MART1, Antigen SK29-AA, Antigen LB39-AA
Anti-MLANA Polyclonal Antibody 是一种 Rabbit 抗体，靶向 MLANA。Anti-MLANA Polyclonal Antibody 可用于 WB。
Anti-MLANA Polyclonal Antibody
Anti-MLANA Polyclonal Antibody
一键复制产品信息 还可以货号 TMAB-01148 别名 Protein Melan-A, MLANA, Melanoma antigen recognized by T-cells 1, MART-1, MART1, Antigen SK29-AA, Antigen LB39-AA
Anti-MLANA Polyclonal Antibody 是一种 Rabbit 抗体，靶向 MLANA。Anti-MLANA Polyclonal Antibody 可用于 WB。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,165 | 5日内发货 | |
| 100 μL | ¥ 1,970 | 5日内发货 | |
| 200 μL | ¥ 2,785 | 5日内发货 |
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| 产品描述 | Anti-MLANA Polyclonal Antibody is a Rabbit antibody targeting MLANA. Anti-MLANA Polyclonal Antibody can be used in WB. |
| 别名 | Protein Melan-A, MLANA, Melanoma antigen recognized by T-cells 1, MART-1, MART1, Antigen SK29-AA, Antigen LB39-AA |
| Ig Type | IgG |
| 反应种属 | Human |
| 验证活性 | 25 μg total protein per Lane of various lysates probed with Melan A polyclonal antibody, unconjugated (TMAB-01148) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at RT for 60 min.  |
| 应用 | WB |
| 推荐剂量 | WB: 1:500-2000 |
| 抗体种类 | Polyclonal |
| 宿主来源 | Rabbit |
| 亚细胞定位 | Endoplasmic reticulum membrane; Single-pass type III membrane protein. Golgi apparatus. Golgi apparatus, trans-Golgi network membrane. Melanosome. Note=Also found in small vesicles and tubules dispersed over the entire cytoplasm. A small fraction of the protein is inserted into the membrane in an inverted orientation. Inversion of membrane topology results in the relocalization of the protein from a predominant Golgi/post-Golgi area to the endoplasmic reticulum. Melanoma cells expressing the protein with an inverted membrane topology are more effectively recognized by specific cytolytic T-lymphocytes than those expressing the protein in its native membrane orientation. |
| 组织特异性 | Expression is restricted to melanoma and melanocyte cell lines and retina. |
| 构建方式 | Polyclonal Antibody |
| 纯化方式 | Protein A purified |
| 性状 | Liquid |
| 缓冲液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 浓度 | 1 mg/mL |
| 研究背景 | Melan A, a product of the MART-1 gene, is a melanocyte differentiation marker recognized by autologous cytotoxic T lymphocytes. Other melanoma-associated markers recognized by autologous cytotoxic T cells are reported to include MAGE-1, MAGE-3, tyrosinase, gp100, gp75, BAGE-1 and GAGE-1. The analysis of these different molecules and their expression in individual melanomas may be of help in the study of their particular molecular roles in melanocyte differentiation and tumorigenesis. |
| 免疫原 | KLH conjugated synthetic peptide: human Melan A |
| 抗原种属 | Human |
| 基因名称 | MLANA |
| 基因ID | |
| 蛋白名称 | Melanoma antigen recognized by T-cells 1 |
| Uniprot ID | |
| 研究领域 | Tumor-associated antigens,Tumor Associated |
| 功能 | Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes. |
| 分子量 | Theoretical: 13 kDa. |
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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