购物车

您的购物车当前为空

RH-5849

Name: RH-5849
Brand: TargetMol
SKU: T19822
Price: 153 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 99.82%

货号 T19822Cas号 112225-87-3

别名 RH5849, RH 5849, 1,2-Dibenzoyl-1-Tert-Butylhydrazine, 1,2-Dibenzoyl-1-(T-Butyl)Hydrazine

RH-5849 (1,2-Dibenzoyl-1-Tert-Butylhydrazine) 是一种新型昆虫生长调节剂，可用作控制橄榄果蝇的潜在杀虫剂。

RH-5849

一键复制产品信息

很棒

纯度: 99.82%

货号 T19822 别名 RH5849, RH 5849, 1,2-Dibenzoyl-1-Tert-Butylhydrazine, 1,2-Dibenzoyl-1-(T-Butyl)HydrazineCas号 112225-87-3

RH-5849 (1,2-Dibenzoyl-1-Tert-Butylhydrazine) 是一种新型昆虫生长调节剂，可用作控制橄榄果蝇的潜在杀虫剂。

规格	价格	库存
25 mg	¥ 153	现货
50 mg	¥ 208	现货
100 mg	¥ 297	现货
1 mL x 10 mM (in DMSO)	¥ 238	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

加入购物车

TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.82%

联系我们获取更多批次信息

资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

RH-5849 AI Summary

RH-5849 exhibits various bioactivities and physicochemical properties conducive for insecticidal applications. It shows good membrane permeability through artificial membranes with a Papp value of 16.52 x 10^-6 cm/s and a moderate hydrophobicity, indicated by a LogP value of 2.45. However, it demonstrates low permeability across Caco-2 cell membranes with LogPapp values of -4.34 and -4.42. The compound has a partition coefficient (LogD) of 2.45 in octanol-buffer and octanol-water and a low dissociation constant (pKa) of 0.0 at pH 7.3. In terms of bioactivity, RH-5849 is a potent inhibitor of DNA Polymerase Beta (IC50 = 89125.1 nM) and GCN5L2 (IC50 = 7079.5 nM). It also exhibits significant ecdysone receptor agonist activity in insect cells, with EC50 values of 1819.7 nM in Drosophila melanogaster B2 cells and 426.58 nM in Bombyx mori Bm5 cells. The compound shows pronounced insecticidal activity against various pests. It is particularly effective against the Oriental armyworm (Mythimna separata), causing 70% mortality at 25 mg/kg and 100% mortality at 50 mg/kg on pretreated corn leaves. Similarly, it shows a high mortality rate in Anastrepha suspensa and Bactrocera oleae, with over 75% mortality and complete mortality at specified concentrations, respectively. Additionally, it exhibits lower efficacy in fufenozide-resistant Plutella xylostella, with an LC50 of 114.2 ug/mL compared to 10.6 ug/mL in susceptible larvae. These findings underscore RH-5849's potential as a selective and effective insecticide, particularly against specific pest species, while also offering utility as a biochemical tool in research concerning ecdysone signaling pathways..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	RH-5849 (1,2-Dibenzoyl-1-Tert-Butylhydrazine) is a novel Insect growth regulator that can be used as a potential insecticide to control olive fruit fly.
别名	RH5849, RH 5849, 1,2-Dibenzoyl-1-Tert-Butylhydrazine, 1,2-Dibenzoyl-1-(T-Butyl)Hydrazine

化学信息

分子量	296.36
分子式	C₁₈H₂₀N₂O₂
CAS No.	112225-87-3
Smiles	CC(C)(C)N(NC(=O)C1=CC=CC=C1)C(=O)C1=CC=CC=C1
密度	1.128g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 55 mg/mL (185.59 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 5 mg/mL (16.87 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3743 mL	16.8714 mL	33.7427 mL	168.7137 mL
5 mM	0.6749 mL	3.3743 mL	6.7485 mL	33.7427 mL
10 mM	0.3374 mL	1.6871 mL	3.3743 mL	16.8714 mL
20 mM	0.1687 mL	0.8436 mL	1.6871 mL	8.4357 mL
50 mM	0.0675 mL	0.3374 mL	0.6749 mL	3.3743 mL
100 mM	0.0337 mL	0.1687 mL	0.3374 mL	1.6871 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

RH-5849

RH-5849

RH-5849

RH-5849 相关产品

产品介绍

计算器

体内实验配液计算器

剂量转换

引用文献

关键词