规格

价格

库存

数量

1 mg

¥ 1,230

现货

5 mg

¥ 3,690

现货

10 mg

¥ 4,790

现货

25 mg

¥ 7,360

现货

50 mg

¥ 9,930

现货

100 mg

¥ 13,300

现货

1 mL x 10 mM (in DMSO)

¥ 3,930

现货

生物活性

产品描述	AZD9567 is a potent and orally active and selective non-steroidal glucocorticoid receptor modulator (SGRM) with an IC50 value of 3.8 nM.It has demonstrated excellent efficacy in the Streptococcus cell wall (SCW) reactivation model of joint inflammation.
靶点活性	GR:3.8 nM
体内活性	AZD9567 (15 mg/kg/天；口服灌胃；每天一次，连续8天；雌性Lewis大鼠；通过关节腔注射5 μg SCW使之敏化) 在SCW大鼠模型中抑制了踝部肿胀。该治疗在大鼠关节炎模型中展现出了卓越的体内效力。[1]
别名	Mizacorat

化学信息

分子量	494.53
分子式	C₂₇H₂₈F₂N₄O₃
CAS No.	1893415-00-3
Smiles	CC(C)[C@H](NC(=O)C(C)(F)F)[C@H](Oc1ccc2n(ncc2c1)-c1ccc(=O)n(C)c1)c1ccccc1
密度	1.26 g/cm3 (Predicted)
颜色	Yellow
物理性状	Solid

储存&溶解度

存储

keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 50 mg/mL (101.11 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2.5 mg/mL (5.06 mM), Sonication is recommeded.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0221 mL	10.1106 mL	20.2212 mL	101.1061 mL
5 mM	0.4044 mL	2.0221 mL	4.0442 mL	20.2212 mL
10 mM	0.2022 mL	1.0111 mL	2.0221 mL	10.1106 mL
20 mM	0.1011 mL	0.5055 mL	1.0111 mL	5.0553 mL
50 mM	0.0404 mL	0.2022 mL	0.4044 mL	2.0221 mL
100 mM	0.0202 mL	0.1011 mL	0.2022 mL	1.0111 mL