规格

价格

库存

数量

1 mg

¥ 736

现货

2 mg

¥ 1,080

5日内发货

5 mg

¥ 1,790

现货

生物活性

产品描述	JI051 is an antitumor agent that interacts with the cancer-associated protein chaperone prohibitin 2 (PHB2) to induce cell cycle arrest by inhibiting the transcription of the Notch downstream effector gene, Hes1, and inhibits the proliferation of HEK293 cells and pancreatic cancer cells.
靶点活性	Cell proliferation:0.3 μM (EC50, HEK293 cell)
体外活性	JI051 (0.1-10 µM, 24 hours) significantly inhibits proliferation of HEK293 cells, exhibiting an EC50 of 0.3 μM, and induces G2/M cell-cycle arrest[1].
别名	JI-051

化学信息

分子量	364.44
分子式	C₂₂H₂₄N₂O₃
CAS No.	2234281-75-3
Smiles	CCOc1ccccc1CCNC(=O)\C=C\c1c[nH]c2c(OC)cccc12
密度	1.187 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 100 mg/mL (274.39 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (10.98 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

JI051