购物车
全部删除 
您的购物车当前为空
RANKL/TNFSF11/CD254 Protein, Human, Recombinant (E. coli)
一键复制产品信息
很棒纯度: 97%
货号 TMPJ-00662
别名 tumor necrosis factor ligand superfamily member 11, TNFSF11, Receptor activator of nuclear factor κ-B ligand, Receptor activator of nuclear factor kappa-B ligand, RANK L, Osteoclast differentiation factor, OPGL, ODF, CD254
CD254, also known as RANKL, TNFSF11, TRANCE, OPGL and ODF, is a type II membrane protein of the tumor necrosis factor (TNF) superfamily, and affects the immune system and control bone regeneration and remodeling. RANKL is the ligand of nuclear factor (NF)-κB (RANK). When RANKL binds to RANK, it will undergo trimerization and then bind to an adaptor molecule TNF receptor-associated factor 6 (TRAF6). This results in the activation of several downstream signaling cascades, including the NFκB, mitogen-activated protein kinases (MAPK), activating protein 1 (AP-1), and nuclear factor of activated T cells (NFATc1), resulting in the formation of multinucleated bone-resorbing osteoclasts. RANKL is widely expressed in skeletal muscle, thymus, liver, colon, small intestine, adrenal gland, osteoblast, mammary gland epithelial cells, prostate and pancreas.
其他形式的 “RANKL/TNFSF11/CD254 Protein, Human, Recombinant (E. coli)”:
RANKL/TNFSF11/CD254 Protein, Human, Recombinant (E. coli)
一键复制产品信息 很棒纯度: 97%
货号 TMPJ-00662 别名 tumor necrosis factor ligand superfamily member 11, TNFSF11, Receptor activator of nuclear factor κ-B ligand, Receptor activator of nuclear factor kappa-B ligand, RANK L, Osteoclast differentiation factor, OPGL, ODF, CD254
CD254, also known as RANKL, TNFSF11, TRANCE, OPGL and ODF, is a type II membrane protein of the tumor necrosis factor (TNF) superfamily, and affects the immune system and control bone regeneration and remodeling. RANKL is the ligand of nuclear factor (NF)-κB (RANK). When RANKL binds to RANK, it will undergo trimerization and then bind to an adaptor molecule TNF receptor-associated factor 6 (TRAF6). This results in the activation of several downstream signaling cascades, including the NFκB, mitogen-activated protein kinases (MAPK), activating protein 1 (AP-1), and nuclear factor of activated T cells (NFATc1), resulting in the formation of multinucleated bone-resorbing osteoclasts. RANKL is widely expressed in skeletal muscle, thymus, liver, colon, small intestine, adrenal gland, osteoblast, mammary gland epithelial cells, prostate and pancreas.
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 5 μg | ¥ 693 | 3日内发货 | |
| 10 μg | ¥ 1,170 | 现货 | |
| 20 μg | ¥ 1,860 | 5日内发货 | |
| 50 μg | ¥ 3,470 | 5日内发货 | |
| 100 μg | ¥ 4,930 | 5日内发货 | |
| 200 μg | ¥ 7,350 | 5日内发货 | |
| 500 μg | ¥ 12,100 | 5日内发货 | |
| 1 mg | ¥ 17,300 | 5日内发货 |
库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单
大包装 & 定制
加入购物车
TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。
产品介绍
生物活性
化学信息
储存&溶解度
| 产品描述 | CD254, also known as RANKL, TNFSF11, TRANCE, OPGL and ODF, is a type II membrane protein of the tumor necrosis factor (TNF) superfamily, and affects the immune system and control bone regeneration and remodeling. RANKL is the ligand of nuclear factor (NF)-κB (RANK). When RANKL binds to RANK, it will undergo trimerization and then bind to an adaptor molecule TNF receptor-associated factor 6 (TRAF6). This results in the activation of several downstream signaling cascades, including the NFκB, mitogen-activated protein kinases (MAPK), activating protein 1 (AP-1), and nuclear factor of activated T cells (NFATc1), resulting in the formation of multinucleated bone-resorbing osteoclasts. RANKL is widely expressed in skeletal muscle, thymus, liver, colon, small intestine, adrenal gland, osteoblast, mammary gland epithelial cells, prostate and pancreas. |
| 生物活性 | Loaded Recombinant Human OPG-Fc on Pro A Biosensor, can bind Human RANKL with an affinity constant of 1.83 pM as determined in BLI assay. (Regularly tested)  |
| 研究背景 | CD254, also known as RANKL, TNFSF11, TRANCE, OPGL and ODF, is a type II membrane protein of the tumor necrosis factor (TNF) superfamily, and affects the immune system and control bone regeneration and remodeling. RANKL is the ligand of nuclear factor (NF)-κB (RANK). When RANKL binds to RANK, it will undergo trimerization and then bind to an adaptor molecule TNF receptor-associated factor 6 (TRAF6). This results in the activation of several downstream signaling cascades, including the NFκB, mitogen-activated protein kinases (MAPK), activating protein 1 (AP-1), and nuclear factor of activated T cells (NFATc1), resulting in the formation of multinucleated bone-resorbing osteoclasts. RANKL is widely expressed in skeletal muscle, thymus, liver, colon, small intestine, adrenal gland, osteoblast, mammary gland epithelial cells, prostate and pancreas. |
| 种属 | Human |
| 表达系统 | E. coli |
| 标签 | Tag Free |
| 蛋白编号 | O14788 |
| 氨基酸序列 | Ile140-Asp317 |
| 蛋白构建 | Ile140-Asp317 |
| 蛋白纯度 | Greater than 90% as determined by reducing SDS-PAGE. Greater than 90% as determined by SEC-HPLC.   |
| 缓冲液 | Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM Tris-HCl, 150 mM NaCl, pH 8.0. |
| 复溶方法 | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
| 别名 | tumor necrosis factor ligand superfamily member 11, TNFSF11, Receptor activator of nuclear factor κ-B ligand, Receptor activator of nuclear factor kappa-B ligand, RANK L, Osteoclast differentiation factor, OPGL, ODF, CD254 |
| 内毒素 | < 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
| 分子量 | 20 KDa (reducing condition) |
| 颜色 | White |
| 物理性状 | Lyophilized powder |
| 运输方式 | In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice. |
| 存储 | Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
计算器
剂量转换
对于不同动物的给药剂量换算，您也可以参考 更多
技术支持
请阅读 重组蛋白用户指南 了解更多具体信息.
图片预览
Related Tags: buy RANKL/TNFSF11/CD254 Protein, Human, Recombinant (E. coli) | purchase RANKL/TNFSF11/CD254 Protein, Human, Recombinant (E. coli) | RANKL/TNFSF11/CD254 Protein, Human, Recombinant (E. coli) cost | order RANKL/TNFSF11/CD254 Protein, Human, Recombinant (E. coli) | RANKL/TNFSF11/CD254 Protein, Human, Recombinant (E. coli) chemical structure | RANKL/TNFSF11/CD254 Protein, Human, Recombinant (E. coli) molecular weight
嗨！有任何问题？点我咨询
版权所有©2015-2025 TargetMol Chemicals Inc.保留所有权利.
沪ICP备20019793号-4 | 沪公网安备 31010602006700号
| 沪(静)应急管危经许[2024]203441