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Anti-Gremlin-1 Antibody (8R57)
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产品编号 TMAY-03032
Anti-Gremlin-1 Antibody (8R57) 是一种 Rabbit 抗体，靶向 Gremlin-1。Anti-Gremlin-1 Antibody (8R57) 可用于 ELISA。
Anti-Gremlin-1 Antibody (8R57)
331 Anti-Gremlin-1 Antibody (8R57)
还可以产品编号 TMAY-03032
Anti-Gremlin-1 Antibody (8R57) 是一种 Rabbit 抗体，靶向 Gremlin-1。Anti-Gremlin-1 Antibody (8R57) 可用于 ELISA。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 100 μL | ¥ 2,279 | 5日内发货 |
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产品介绍
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偶联与修饰
抗原信息
| 产品描述 | Anti-Gremlin-1 Antibody (8R57) is a Rabbit antibody targeting Gremlin-1. Anti-Gremlin-1 Antibody (8R57) can be used in ELISA. |
| Ig Type | Rabbit IgG |
| 克隆号 | 8R57 |
| 交叉反应 | Mouse |
| 应用 | ELISA |
| 推荐剂量 | ELISA: 1:5000-1:10000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse GREM1 (O70326Met1-Asp184). |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | GREM1 belongs to the DAN family. It contains 1 CTCK (C-terminal cystine knot-like) domain. GREM1 is a cysteine knot-secreted protein and acts as an inhibitor in the TGF beta signaling pathway. It inhibits BMP-2, -4, and -7. Inhibition by Grem 1 of BMPs in mice allows the expression of fibroblast growth factors (FGFs) 4 and 8 and Sonic hedgehog (Shh) which are necessary for proper limb development. It interacts with SLIT1 and SLIT2 in a glycosylation-dependent manner. As a cytokine, GREM1 may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. It down-regulates the BMP4 signaling in a dose-dependent manner. It also acts as an inhibitor of monocyte chemotaxis. GREM1 is highly expressed in the small intestine, fetal brain, and colon. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein: Mouse GREM1 protein |
| 抗原种属 | Mouse |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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