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顶部生物活性储存和溶解信息计算器

Anti-Gremlin-1 Antibody (8R57)

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产品编号 TMAY-03032

Anti-Gremlin-1 Antibody (8R57) 是一种 Rabbit 抗体，靶向 Gremlin-1。Anti-Gremlin-1 Antibody (8R57) 可用于 ELISA。

Anti-Gremlin-1 Antibody (8R57)

Anti-Gremlin-1 Antibody (8R57)

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Rating icon 还可以
产品编号 TMAY-03032

Anti-Gremlin-1 Antibody (8R57) 是一种 Rabbit 抗体，靶向 Gremlin-1。Anti-Gremlin-1 Antibody (8R57) 可用于 ELISA。

规格价格库存数量
100 μL
¥ 2,279
5日内发货
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产品介绍

生物活性
产品描述
Anti-Gremlin-1 Antibody (8R57) is a Rabbit antibody targeting Gremlin-1. Anti-Gremlin-1 Antibody (8R57) can be used in ELISA.
Ig Type
Rabbit IgG
克隆号
8R57
交叉反应
Mouse
特异性
Mouse Gremlin 1/GREM1
应用ELISA
推荐剂量
ELISA: 1:5000-1:10000
抗体种类
Monoclonal
宿主来源Rabbit
构建方式This antibody was obtained from a rabbit immunized with purified, recombinant Mouse GREM1 (O70326Met1-Asp184).
纯化方式Protein A
性状Liquid
缓冲液0.2 μm filtered solution in PBS
研究背景GREM1 belongs to the DAN family. It contains 1 CTCK (C-terminal cystine knot-like) domain. GREM1 is a cysteine knot-secreted protein and acts as an inhibitor in the TGF beta signaling pathway. It inhibits BMP-2, -4, and -7. Inhibition by Grem 1 of BMPs in mice allows the expression of fibroblast growth factors (FGFs) 4 and 8 and Sonic hedgehog (Shh) which are necessary for proper limb development. It interacts with SLIT1 and SLIT2 in a glycosylation-dependent manner. As a cytokine, GREM1 may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. It down-regulates the BMP4 signaling in a dose-dependent manner. It also acts as an inhibitor of monocyte chemotaxis. GREM1 is highly expressed in the small intestine, fetal brain, and colon.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein: Mouse GREM1 protein
抗原种属
Mouse
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
运输方式Shipping with blue ice.

计算器

  • 稀释 计算器

关键词

Gremlin-1Gremlin1Grem1Grem 1DrmDown-regulated in Mos-transformed cells proteinCysteine knot superfamily 1, BMP antagonist 1Cktsf1b1Cktsf1b 1

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