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anti-TNBC agent-1

anti-TNBC agent-1

产品编号 T39815   CAS 2289585-58-4

anti-TNBC agent-1 is a highly effective compound specifically designed to target and combat triple-negative breast cancer (TNBC). It demonstrates remarkable potency against various breast cancer cell types, with IC50 values spanning from 0.20 μM to 0.27 μM. The mechanism of action of anti-TNBC agent-1 involves inducing apoptosis in SUM-159 cells through the mitochondria pathway, as well as causing G1 phase arrest in these cells.

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anti-TNBC agent-1 Chemical Structure
anti-TNBC agent-1, CAS 2289585-58-4
规格 价格/CNY 货期 数量
25 mg ¥ 10,600 待询
药物设计专题培训
千万补贴 助力科研
BCA蛋白浓度测定试剂盒限时半价
产品目录号及名称: anti-TNBC agent-1 (T39815)
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参考文献
产品描述 anti-TNBC agent-1 is a highly effective compound specifically designed to target and combat triple-negative breast cancer (TNBC). It demonstrates remarkable potency against various breast cancer cell types, with IC50 values spanning from 0.20 μM to 0.27 μM. The mechanism of action of anti-TNBC agent-1 involves inducing apoptosis in SUM-159 cells through the mitochondria pathway, as well as causing G1 phase arrest in these cells.
体外活性 anti-TNBC agent-1 (compound 7) exhibits potent activity against MDA-MB231, SUM-159, MCF-7, Bcap-37, 4T1 cells with IC 50 values ranging from 0.20 μM to 0.27 μM. anti-TNBC agent-1 shows 11.6- to 18.6-fold improvement comparing to that of the parent compound parthenolide with IC50 values of 2.68-4.63 μM. anti-TNBC agent-1 is more active than the positive control drug Adriamycin (ADR)[1]. anti-TNBC agent-1 (2 μM and 5 μM; 48 hours; SUM-159 cells) exhibits significant stronger effect on induction of cell apoptosis compared with that of Parthenolide[1]. anti-TNBC agent-1 has selective cytotoxicity against breast cancer cells (IC 50 =0.22 μM) being compared with 3T3 cells (IC 50 =8.13 μM)[1].
分子量 454.519
分子式 C26H30O7
CAS No. 2289585-58-4

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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TargetMol Library Books参考文献

1. Ge W, et al. Synthesis and structure-activity relationship studies of parthenolide derivatives as potential anti-triple negative breast cancer agents. Eur J Med Chem. 2019;166:445-469.

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Keywords

anti-TNBC agent-1 2289585-58-4 anti TNBC agent 1 antiTNBC agent1 Inhibitor inhibitor inhibit

 

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