Bucindolol

Name: Bucindolol
Brand: TargetMol
SKU: T10631
Price: 591 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.9%

货号 T10631Cas号 71119-11-4

别名 布新洛尔, MJ 131051, MJ 13105, BMY 13105

Bucindolol (BMY 13105) 是一种新型有效的 β1 肾上腺素能受体 (β1-adrenergic receptor) 阻滞剂，可介导血管舒张，可用于研究慢性心力衰竭。

Bucindolol

一键复制产品信息

很棒

纯度: 99.9%

货号 T10631 别名 布新洛尔, MJ 131051, MJ 13105, BMY 13105Cas号 71119-11-4

Bucindolol (BMY 13105) 是一种新型有效的 β1 肾上腺素能受体 (β1-adrenergic receptor) 阻滞剂，可介导血管舒张，可用于研究慢性心力衰竭。

规格	价格	库存
1 mg	¥ 397	现货
2 mg	¥ 591	现货
5 mg	待询	现货

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纯度: 99.9%

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COA LCMS HNMR 产品操作手册

产品介绍

Bucindolol AI Summary

Bucindolol exhibits a wide range of bioactivities across various biological systems. It acts as a beta-adrenergic receptor blocker in normotensive rats, achieving 71.0% inhibition at 2 mg/kg, and demonstrates intrinsic sympathomimetic activity with 77.0 beats per minute in reserpinized rats. Additionally, it shows antihypertensive effects in spontaneously hypertensive rats with a 45.0 mmHg reduction in blood pressure following peroral administration and possesses vasodilator activity in ganglion-blocked rats, leading to a 26.0% decrease in mean arterial blood pressure at 3 mg/kg intravenously. Bucindolol is a potent inhibitor of the enzyme Cytochrome P450 2D6 (CYP2D6), with an IC50 value of 50.0 nM after 45 minutes of incubation. It also significantly inhibits the uptake of 4-(4-(dimethylamino)styryl)-N-methylpyridinium via human OCT1 in HEK293 cells, with an IC50 of 27,200.0 nM and 84.6% inhibition at a concentration of 100 µM. The compound shows diverse bioactivity in various other assays, including inhibition of the Menin-MLL interaction in MLL-related leukemias, GCN5L2 inhibition, delayed death inhibition of the malarial parasite plastid, and Schwann cell viability assays. Additionally, it induces DNA re-replication in SW480 colon adenocarcinoma cells, inhibits human tyrosyl-DNA phosphodiesterase 1 (TDP1), blocks viral entries, including Lassa Virus, Marburg Virus, Ebola Virus, and SARS-CoV-2, with an IC50 ranging from 16,982.44 nM to 17,000.0 nM for SARS-CoV-2. The compound also inhibits insulin secretion from INS-1E cells at different glucose concentrations, with varying potencies in the nanomolar and micromolar ranges. Lastly, Bucindolol exhibits antiviral activity against SARS-CoV-2 in VERO-E6 cells, demonstrating an IC50 range of 16,982.44 nM to 17,000.0 nM and a CC50 value of 30,900.0 nM, indicating both its potency and certain cytotoxicity to VERO-E6 cells..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Bucindolol (BMY 13105) is a novel and potent β1-adrenergic receptor blocker that mediates vasodilation and can be used to study chronic heart failure.
别名	布新洛尔, MJ 131051, MJ 13105, BMY 13105

化学信息

分子量	363.45
分子式	C₂₂H₂₅N₃O₂
CAS No.	71119-11-4
Smiles	CC(C)(Cc1c[nH]c2ccccc12)NCC(O)COc1ccccc1C#N
密度	1.31g/cm3

储存&溶解度

存储

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 80 mg/mL (220.11 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7514 mL	13.7571 mL	27.5141 mL	137.5705 mL
5 mM	0.5503 mL	2.7514 mL	5.5028 mL	27.5141 mL
10 mM	0.2751 mL	1.3757 mL	2.7514 mL	13.7571 mL
20 mM	0.1376 mL	0.6879 mL	1.3757 mL	6.8785 mL
50 mM	0.0550 mL	0.2751 mL	0.5503 mL	2.7514 mL
100 mM	0.0275 mL	0.1376 mL	0.2751 mL	1.3757 mL