Name: NT1-O12B
Brand: TargetMol
SKU: T38093
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

5 mg

¥ 2,802

待询

10 mg

¥ 4,665

待询

25 mg

¥ 8,877

待询

50 mg

¥ 13,737

待询

100 mg

¥ 20,217

待询

1 mL x 10 mM (in DMSO)

¥ 4,414

待询

生物活性

产品描述	NT1-O12B, an endogenous neurotransmitter-derived lipidoid (NT-lipidoid), serves as a highly efficient carrier for enhancing the transportation of various blood-brain barrier (BBB)-impermeable cargos to the brain. Incorporating NT1-O12B into BBB-impermeable lipid nanoparticles (LNPs) enables these LNPs to effectively traverse the BBB. In addition to enabling cargo passage through the BBB, NT-lipidoid formulations facilitate efficient delivery of the cargo into neuronal cells for purposes such as functional gene silencing or gene recombination[1].
体外活性	NT1-O12B indicates a lipidoid containing a tryptamine head group and a hydrophobic tail group containing 12 carbon atoms[1].
体内活性	It encapsulates AmB in pure NT1-lipidoids (namely NT1-O12B, NT1-O14B, NT1-O16B, and NT1-O18B) using a procedure similar to the DiR encapsulation. NT1-O12B is the dopant for enhanced brain delivery because it shows the highest DiR fluorescence intensity among all NT-lipidoids. Doping NT1-O12B to the BBB-impermeable lipidoid PBA-Q76-O16B resulted in an AmB formulation that could cross BBB. Using this approach, the AmB concentration in the brain tissue reached as high as 300 ng/g (AmB/tissue) with a delivery efficiency of about 0.135% of injected dose after 24 hours of intravenous injection with AmB (5 mg/kg)[1].
别名	NT1-O12B

化学信息

Smiles

#N/A

储存&溶解度

存储	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year
溶解度信息	DMSO: 200 mg/mL, Sonication is recommended.
体内实验配方	10% DMSO+90% Corn Oil: 5 mg/mL, Sonication is recommeded. 请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。