Name: Evunzekibart
Brand: TargetMol
SKU: T80578
Price: 2880 CNY
Availability: InStock
Rating: 5 (10 reviews)

规格

价格

库存

数量

1 mg

¥ 2,880

现货

5 mg

¥ 7,880

现货

10 mg

¥ 12,300

现货

25 mg

¥ 22,800

现货

50 mg

¥ 36,500

现货

生物活性

产品描述	Evunzekibart is a human monoclonal antibody and a Fcγ receptor-dependent 4-1BB (CD137/TNFRSF9) agonist. Evunzekibart exerts potent antitumor immune activity by selectively activating effector T cells and NK cells in the tumor microenvironment. Evunzekibart is being investigated as a monotherapy or in combination with anti-PD-1/PD-L1 agents for the treatment of advanced solid tumors.
体外活性	方法：人 NK 细胞经 IL-2（10 ng/mL）预刺激 24 h，与紫外线灭活的 FcγRI-CHO 细胞、梯度 Evunzekibart (0.002–50 nM) 共孵育 24-72 h，补充 IL-2 维持活化。收集上清，ELISA 检测 IFNγ、颗粒酶 B 水平。结果：Evunzekibart显著活化 NK 细胞，提高 IFNγ、颗粒酶 B 水平。[1]
体内活性	方法：为研究 Evunzekibart 肿瘤效果，构建人源化 4-1BB 敲入小鼠 (C57BL/6)，皮下移植MC38 结肠癌细胞构建肿瘤模型，接种成功后腹腔注射 Evunzekibart (10, 100, 200 μg) ，每周两次，持续3 周。结果： Evunzekibart 剂量依赖性的抑制肿瘤生长，且在200 μg 时完全抑制，提高小鼠生存率。[1]
别名	ATOR-1017, ATOR1017, ATOR 1017
反应种属	Human
应用	ELISA FACS Functional assay
抗体种类	Monoclonal
缓冲液	Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition.
内毒素	<1 EU/mg

抗体信息

同型	Human IgG4 kappa
推荐同型对照	Human IgG4 (S228P) kappa, Isotype Control

偶联与修饰

偶联	Unconjugated

抗原信息

Uniprot ID	Q07011
靶点	4-1BB

化学信息

CAS No.

2639688-77-8

储存&溶解度

存储	Store at low temperature Store at -20°C Shipping with blue ice/Shipping at ambient temperature. 实际储存温度请以COA为准

Evunzekibart